{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:51:24Z","timestamp":1774612284220,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,19]],"date-time":"2004-10-19T00:00:00Z","timestamp":1098144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Deep sedation is being provided at an increasing rate for patients undergoing bone marrow biopsy and aspiration (BMBA). The aim of this study was to establish the safety of deep sedation used for adults undergoing BMBA. A nonrandomized database analysis and retrospective review of patient records from January 1997 to December 2000 was performed; 5,811 patients were identified as having undergone their first outpatient BMBA. Outcome measures included 30\u2010day mortality and same\u2010day hospital admission; surrogate measures included need for a surgical procedure or receipt of red blood cells within the 48 hr following the BMBA. Patients who received intravenously administered midazolam, fentanyl, and propofol for maintenance of deep sedation plus infiltration of a local anesthetic (<jats:italic>n<\/jats:italic> = 2,604; 45%) comprised the deep sedation group; those who received infiltration of a local anesthetic but no intravenous sedation or analgesia (<jats:italic>n<\/jats:italic> = 3,207; 55%) comprised the local anesthesia group. Patients in the deep sedation group compared to those in the local anesthesia group were less likely to die within 30 days (0.69% vs. 1.34%, <jats:italic>P<\/jats:italic> = 0.018) and less likely to receive red blood cells (1.27% vs. 2.25%, <jats:italic>P<\/jats:italic> = 0.006). No other differences between the groups were found. Although the study was retrospective and nonrandomized, the results suggest that the use of deep sedation for outpatient BMBA is as safe as using local anesthesia. Am. J. Hematol. 77:250\u2013256, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20185","type":"journal-article","created":{"date-parts":[[2004,10,19]],"date-time":"2004-10-19T19:43:18Z","timestamp":1098214998000},"page":"250-256","source":"Crossref","is-referenced-by-count":22,"title":["Morbidity and mortality of deep sedation in outpatient bone marrow biopsy"],"prefix":"10.1002","volume":"77","author":[{"given":"Christopher M.","family":"Burkle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry A.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa F.","family":"Koenig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Decker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David O.","family":"Warner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis A.","family":"Gastineau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.10.737"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.9.657"},{"key":"e_1_2_1_4_2","first-page":"17","volume-title":"Williams hematology","author":"Ryan DH","year":"2001"},{"key":"e_1_2_1_5_2","first-page":"2460","volume-title":"Hematology: basic principles and practice","author":"Ryan DH","year":"2000"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199905000-00005"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2000.n.014"},{"issue":"11","key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1001\/jama.1989.03420110075027","article-title":"Standard of care and anesthesia liability","volume":"261","author":"Cheney FW","year":"1989","journal-title":"J Am Med Assoc"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.4065\/71.3.266"},{"key":"e_1_2_1_10_2","first-page":"1","volume-title":"Aust NZ Coll Anaesth Mort Rep","author":"Mackay P","year":"2002"},{"key":"e_1_2_1_11_2","volume-title":"JCAHO Compliance Tool Kit Sedation Model","author":"American Society of Anesthesiologists","year":"2004"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.40.6.696"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(03)00312-9"},{"key":"e_1_2_1_14_2","first-page":"126","volume-title":"Pharmacology and physiology in anesthetic practice","author":"Stoelting RK","year":"1999"},{"issue":"4","key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1365-2257.1996.tb01295.x","article-title":"The role of midazolam\u2010induced sedation in bone marrow aspiration\/trephine biopsies","volume":"18","author":"Mainwaring CJ","year":"1996","journal-title":"Clin Lab Haematol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8537(02)00081-0"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200017030-00003"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200207001-00002"},{"key":"e_1_2_1_19_2","first-page":"1260","volume-title":"Principles and practice of anesthesiology","author":"Gupta VL","year":"1998"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04329.x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.68.803.770"},{"issue":"10","key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1001\/jama.1980.03310100034026","article-title":"Complications associated with ambulatory surgery","volume":"244","author":"Natof HE","year":"1980","journal-title":"J Am Med Assoc"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03008707"},{"issue":"12","key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1001\/jama.1993.03510120059031","article-title":"Major morbidity and mortality within 1 month of ambulatory surgery and anesthesia","volume":"270","author":"Warner MA","year":"1993","journal-title":"J Am Med Assoc"},{"issue":"42","key":"e_1_2_1_25_2","first-page":"1611","article-title":"Errors and hazards: fatalities through sternal puncture","volume":"110","author":"Puschel K","year":"1985","journal-title":"Dtsch Med Wochenschr"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200308000-00006"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.14.1705"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2001.117139"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.20185","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.20185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T23:24:30Z","timestamp":1700263470000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.20185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10,19]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1002\/ajh.20185"],"URL":"https:\/\/doi.org\/10.1002\/ajh.20185","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10,19]]}}}