{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:20:52Z","timestamp":1781796052567,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,19]],"date-time":"2004-10-19T00:00:00Z","timestamp":1098144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mastocytosis is characterized by mast cell proliferation that may be limited to the skin (cutaneous mastocytosis) or may involve one or more extracutaneous organs, e.g., the bone marrow (systemic mastocytosis; SM). This study objective is to evaluate the features and outcome of patients referred to M. D. Anderson Cancer Center (MDACC) with SM. A search of the MDACC database from 1944 to 2002 was conducted for patients with SM and review of their clinical charts. Eighteen patients with mastocytosis were identified in the MDACC database; 15 (11 males and 4 females) had SM and available information. Two had associated myelodysplastic syndrome (MDS), and one had acute myeloid leukemia (AML). The median age was 58 years (range 31\u201380). Nine patients were treated with subcutaneous interferon\u2010alpha, and only 1 experienced temporary control of the disease. Three of these patients were then treated with imatinib mesylate: transient improvement was noted in two patients. One patient underwent stem cell transplantation as first therapy and achieved complete remission; this patient had associated MDS and is now in complete remission for 8 years. The patient with associated AML was treated with high\u2010dose cytarabine and idarubicin; he has been in complete remission for 16 months. One patient was treated with induction chemotherapy consisting of high\u2010dose cytarabine and 2CDA but expired due to sepsis. Three patients received symptomatic therapy only; these were the only 3 patients who presented with normal blood counts. SM is rare and has no effective standard of care. Collaboration among academic centers to accrue enough patients to evaluate novel therapeutic strategies is needed. Am. J. Hematol. 77:209\u2013214, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20211","type":"journal-article","created":{"date-parts":[[2004,10,19]],"date-time":"2004-10-19T19:24:16Z","timestamp":1098213856000},"page":"209-214","source":"Crossref","is-referenced-by-count":44,"title":["Management of patients with systemic mastocytosis: Review of M. D. Anderson Cancer Center experience"],"prefix":"10.1002","volume":"77","author":[{"given":"Bryan","family":"Hennessy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Giles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Cortes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Ferrajoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladys","family":"Ossa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Garcia\u2010Manero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Faderl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagop","family":"Kantarjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srdan","family":"Verstovsek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.4065\/77.11.1169"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70295-1"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(02)00168-6"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10322"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(03)00065-1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(01)00038-8"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199609054789"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.9.898"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02131.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830470121"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb08689.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00663015"},{"key":"e_1_2_1_14_2","first-page":"309","article-title":"Interferons in the treatment of malignant mastocytosis (MM) and CMMol","volume":"55","author":"Griesinger F","year":"1987","journal-title":"Blut"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70301-4"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)62636-6"},{"key":"e_1_2_1_17_2","first-page":"385","article-title":"Biology, classification and treatment of human mastocytosis","volume":"108","author":"Valent P","year":"1996","journal-title":"Wien Klin Wochenschr"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.4.1609"},{"key":"e_1_2_1_19_2","first-page":"33","article-title":"Mastocytosis: classification, diagnosis, and clinical presentation","volume":"25","author":"Castells MC","year":"2004","journal-title":"Allergy Asthma Proc"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12468899"},{"key":"e_1_2_1_21_2","first-page":"64","article-title":"Interferon alpha and pamidronate: a useful combination in the treatment of osteoporosis and systemic mastocytosis (letter)","volume":"27","author":"Brunel V","year":"1998","journal-title":"Presse Med"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002770000206"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002770050604"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199202273260907"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.1994.tb00423.x"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.37.484"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03944.x"},{"key":"e_1_2_1_28_2","first-page":"345","article-title":"Interferon alpha and systemic mastocytosis. Analysis of therapeutic efficacy in 6 cases (article in Spanish)","volume":"198","author":"Giraldo Castellano P","year":"1998","journal-title":"Rev Clin Esp"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1998.9694832"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(02)00073-5"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101253440415"},{"key":"e_1_2_1_32_2","first-page":"197","article-title":"Systemic mastocytosis: current concepts and treatment advances","volume":"3","author":"Tefferi A","year":"2004","journal-title":"Curr Hematol Rep"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12469045"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830380319"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90214-I"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880901)62:5<965::AID-CNCR2820620520>3.0.CO;2-M"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199801)57:1<24::AID-AJH4>3.0.CO;2-3"},{"key":"e_1_2_1_38_2","first-page":"413","article-title":"Persistence of systemic mastocytosis after allogeneic bone marrow transplantation in spite of complete remission of the associated myelodysplastic syndrome","volume":"8","author":"Ronnov\u2010Jessen D","year":"1991","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1080\/1042819021000046976"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(03)00089-3"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04575.x"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(99)00145-9"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1627"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08505-7"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.5.1741"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14115-3"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200401000-00009"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.20211","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.20211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T23:25:10Z","timestamp":1700263510000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.20211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10,19]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1002\/ajh.20211"],"URL":"https:\/\/doi.org\/10.1002\/ajh.20211","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10,19]]}}}