{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T22:43:34Z","timestamp":1700174614357},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,31]],"date-time":"2005-05-31T00:00:00Z","timestamp":1117497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe a patient who developed myelodysplastic syndrome over 2 years after achieving complete remission of acute myeloid leukemia (AML). The patient was treated in July 1998 with anthracycline, etoposide, and behenoyl cytarabine chemotherapy for AML (French\u2010American\u2010British classification, M2; World Health Organization classification, AML with maturation) and achieved complete remission. At presentation, no chromosomal abnormalities were detected. In December 2000, the patient's peripheral blood revealed pancytopenia, and his bone marrow was hypocellular with trilineage myelodysplasia and no blasts. Chromosomal analysis revealed complex karyotypic abnormalities, including monosomy 5. The patient was diagnosed with high\u2010grade myelodysplastic syndrome (MDS)\/refractory anemia with excess blasts (RAEB) subtype. The pancytopenia progressed rapidly, and he died 2 months after the diagnosis of MDS. Therapy\u2010related MDS and AML (t\u2010MDS\/t\u2010AML) developing after treatment for acute leukemia is unusual; the primary leukemia associated with most cases of t\u2010MDS\/t\u2010AML is acute promyelocytic leukemia (APL). This unusual case suggests that AML excluding APL should be considered a primary hematologic malignancy for t\u2010MDS\/t\u2010AML. Am. J. Hematol. 79:136\u2013141, 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20329","type":"journal-article","created":{"date-parts":[[2005,5,31]],"date-time":"2005-05-31T20:16:51Z","timestamp":1117570611000},"page":"136-141","source":"Crossref","is-referenced-by-count":7,"title":["Therapy\u2010related myelodysplastic syndrome with monosomy 5 after successful treatment of acute myeloid leukemia (M2)"],"prefix":"10.1002","volume":"79","author":[{"given":"Toshie","family":"Ogasawara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Yasuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyotaka","family":"Kawauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,31]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"671","article-title":"Acute myeloid leukemia after treatment with cytostatic agents","volume":"26","author":"Sypkens CG","year":"1970","journal-title":"Lancet"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1986.4.3.325"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a058121"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.5.945"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1199"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.9.3542.bloodjournal8693542"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1182\/blood.V79.7.1892.1892","article-title":"Balanced translocations involving chromosome bands 11q23 and 21q22 in therapy\u2010related acute myeloid leukemia","volume":"79","author":"Larson RA","year":"1992","journal-title":"Blood"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.07.113"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3343"},{"key":"e_1_2_1_11_2","first-page":"102","article-title":"A therapy\u2010related myelodysplastic syndrome with unusual features in a patient treated for acute promyelocytic leukemia","volume":"86","author":"Pecci A","year":"2001","journal-title":"Haematologica"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190290006044"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.3.822"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402616"},{"key":"e_1_2_1_15_2","first-page":"97","article-title":"No beneficial effect of etoposide added to daunorubicin, cytarabine and 6\u2010mercaptopurine individualized induction therapy of adult acute myeloid leukemia: the JALSG\u2010AML92 Study","volume":"70","author":"Miyawaki S","year":"1999","journal-title":"Int J Hematol"},{"key":"e_1_2_1_16_2","first-page":"319","article-title":"Early onset invasive pulmonary zygomycosis following allogeneic peripheral blood stem cell transplantation in a patient with therapy\u2010related myelodysplastic syndrome","volume":"45","author":"Kawakami K","year":"2004","journal-title":"Jpn J Clin Hematol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02982025"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860801)58:3<630::AID-CNCR2820580306>3.0.CO;2-E"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.4.1333.1333"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.10.1707"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.10.2780.2780"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.20329","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.20329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T22:23:24Z","timestamp":1700173404000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.20329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,31]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1002\/ajh.20329"],"URL":"https:\/\/doi.org\/10.1002\/ajh.20329","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5,31]]}}}