{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:25:43Z","timestamp":1777418743834,"version":"3.51.4"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,31]],"date-time":"2005-05-31T00:00:00Z","timestamp":1117497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hb\u2010M is a very rare hemoglobinopathy in the Indian subcontinent. We report a family with Hb\u2010M with lifelong cyanosis from the Ratnagiri district in western India. The propositus was a 11\u2010year\u2010old female child with a history of increasing cyanosis exacerbated by fever and weakness. Similar complaints were also noted in her mother and five maternal family members. There was no history of cardiac illness or exposure to drugs and chemicals. The methemoglobin level was 39.3% in the propositus and 21.1% in her mother with normal NADH\u2010methemoglobin reductase activity. Abnormal absorption peaks by spectroscopic analysis, presence of hemoglobin instability, and a slow\u2010moving band on starch gel electrophoresis supported the presence of Hb\u2010M. Automated DNA sequence analysis of the \u03b2 globin gene showed a C\u2192T substitution at codon 63. This leads to a substitution of histidine (CAT) by tyrosine (TAT) at the \u03b2 63 (E7) position, similar to Hb\u2010M Saskatoon. We have named this variant as Hb\u2010M<jats:sub>Ratnagiri<\/jats:sub>. Am. J. Hematol. 79:168\u2013170, 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20368","type":"journal-article","created":{"date-parts":[[2005,5,31]],"date-time":"2005-05-31T22:16:58Z","timestamp":1117577818000},"page":"168-170","source":"Crossref","is-referenced-by-count":14,"title":["Congenital methemoglobinemia caused by Hb\u2010M<sub>Ratnagiri<\/sub> (\u03b2\u201063CAT\u2192TAT, His\u2192Tyr) in an Indian family"],"prefix":"10.1002","volume":"79","author":[{"given":"Prabhakar S.","family":"Kedar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita H.","family":"Nadkarni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supriya","family":"Phanasgoankar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manisha","family":"Madkaikar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanjaksha","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajit C.","family":"Gorakshakar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roshan B.","family":"Colah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipika","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,31]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"81","article-title":"Enzymopenic hereditary methaemoglobinemia: a clinical\/biochemical classification","volume":"12","author":"Jaffe ER","year":"1986","journal-title":"Blood Cells"},{"key":"e_1_2_1_3_2","first-page":"1046","volume-title":"Wintrobe's clinical hematology","author":"Lukens JN","year":"1999"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1182\/blood.V13.10.936.936","article-title":"Electrophoretic and spectroscopic characterization of Hb\u2010M","volume":"13","author":"Gerald PS","year":"1958","journal-title":"Blood"},{"key":"e_1_2_1_5_2","first-page":"249","volume-title":"Practical hematology","author":"Dacie JV","year":"1999"},{"key":"e_1_2_1_6_2","first-page":"655","article-title":"Microdetermination of oxyhemoglobin, methemoglobin and sulphemoglobin in a single sample of blood","volume":"26","author":"Evelyn KA","year":"1938","journal-title":"J Biochem"},{"key":"e_1_2_1_7_2","first-page":"38","volume-title":"A manual of biochemical methods","author":"Beutler E","year":"1975"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1972.tb00987.x"},{"key":"e_1_2_1_9_2","first-page":"383","article-title":"Hemoglobin\u2010M disease: a case report","volume":"10","author":"Bajaj RT","year":"1973","journal-title":"Ind Pediatr"},{"key":"e_1_2_1_10_2","first-page":"54","article-title":"Hemoglobin\u2010M disease in a Punjabi Hindu family","volume":"18","author":"Das K C","year":"1975","journal-title":"Ind J Pathol Bacteriol"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.20368","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.20368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T22:24:01Z","timestamp":1700173441000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.20368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,31]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1002\/ajh.20368"],"URL":"https:\/\/doi.org\/10.1002\/ajh.20368","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5,31]]}}}