{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:40:13Z","timestamp":1761100813559},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,10,24]],"date-time":"2005-10-24T00:00:00Z","timestamp":1130112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluate whether molecular monitoring of minimal residual disease (MRD) using TCR \u03b4 (TCRD), TCR \u03b3 (TCRG), and immunoglobulin H (IgH) gene rearrangements in the bone marrow (BM) is correlated with clinical events in ALL patients. The 14 patients enrolled in this study included 6 males and 8 females with a median age of 53 years (range, 25\u201379 years), and the median duration of follow\u2010up was 417 days (range, 57\u2013617 days). The median WBC count was 11.3 \u00d7 10<jats:sup>9<\/jats:sup>\/L at diagnosis. All patients had L2 type ALL. Eleven patients had a monoclonal pattern of IgH (7), TCRD (3) and TCRG (1), and 3 patients had two clonal patterns. Eleven of the 14 patients achieved the first complete remission (CR) after the first induction chemotherapy. We analyzed 9 of 11 CR patients who could be examined immediately after induction chemotherapy (including re\u2010induction therapy). Event\u2010free survival (EFS, 0%) and disease\u2010free survival (DFS, 0%) at 1 year in CR patients with MRD level \u226510<jats:sup>\u22123<\/jats:sup> (<jats:italic>n<\/jats:italic> = 3) were significantly lower than those in CR patients with MRD level &lt;10<jats:sup>\u22123<\/jats:sup> (<jats:italic>n<\/jats:italic> = 6) (log\u2010rank test, <jats:italic>P<\/jats:italic> = 0.013, 0.013). A lower MRD in BM value after induction chemotherapy was associated significantly with longer survival in the log\u2010rank test. Our data provide evidence that molecular MRD status of BM is a strong predictor of outcome in adult ALL. Am. J. Hematol. 80:181\u2013187, 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20461","type":"journal-article","created":{"date-parts":[[2005,10,24]],"date-time":"2005-10-24T15:48:32Z","timestamp":1130168912000},"page":"181-187","source":"Crossref","is-referenced-by-count":17,"title":["Minimal residual disease (MRD) monitoring using rearrangement of T\u2010cell receptor and immunoglobulin H gene in the treatment of adult acute lymphoblastic leukemia 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