{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T14:49:34Z","timestamp":1784386174162,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,20]],"date-time":"2005-12-20T00:00:00Z","timestamp":1135036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with a central venous catheter (CVC) undergoing high\u2010dose chemotherapy (HDC) followed by peripheral\u2010blood stem\u2010cell transplantation (PBSCT) for malignancies are at high risk of thrombosis, but the use of anti\u2010coagulant prophylaxis remains debatable in this setting of patients. We analyzed the efficacy and the safety of minidose warfarin in 228 patients in whom CVCs had been placed and who had received 292 HDC courses of therapy. The catheters remained in place for a mean of 173 (range 40\u2013298) days. All patients received prophylactic oral warfarin in the fixed dose of 1 mg\/day starting on the day of CVC insertion. Prophylaxis was interrupted during aplasia when platelet counts fell below 50,000\/dL. There were no toxic deaths related to the prophylaxis. Overall there were 4 thrombotic events. Three occurrences were directly related to the catheter, while the remaining event was a deep saphenous\u2010vein thrombosis. A number of potential predictive factors were analyzed for their impact on thrombotic events without finding any significant correlation. Four episodes of bleeding occurred, with each of these individuals having a normal INR but a platelet count below 50,000\/dL. Minidose warfarin is effective and safe to use for preventing thrombotic events in this setting of patients. Am. J. Hematol. 81:1\u20134, 2006. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20512","type":"journal-article","created":{"date-parts":[[2005,12,20]],"date-time":"2005-12-20T23:21:18Z","timestamp":1135120878000},"page":"1-4","source":"Crossref","is-referenced-by-count":22,"title":["Prophylaxis of central venous catheter\u2010related thrombosis with minidose warfarin in patients treated with high\u2010dose chemotherapy and peripheral\u2010blood stem\u2010cell transplantation: Retrospective analysis of 228 cancer patients"],"prefix":"10.1002","volume":"81","author":[{"given":"Massimo","family":"Magagnoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Masci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Castagna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Pedicini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Poretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Morenghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Brambilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-199512000-00002"},{"key":"e_1_2_1_3_2","first-page":"87","article-title":"Central venous catheter\u2010related complications after bone marrow transplantation in children with hematological malignancies","volume":"17","author":"Uderzo C","year":"1992","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950180309"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/014860718200600161"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02303635"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900901)66:5<900::AID-CNCR2820660515>3.0.CO;2-A"},{"key":"e_1_2_1_8_2","first-page":"235","article-title":"Catheter\u2010related thrombosis in patients with refractory lymphoma undergoing autologous stem cell transplantation","volume":"7","author":"Conlan MG","year":"1991","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-76-3-112-6-423"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00732.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.02.042"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg238"},{"key":"e_1_2_1_13_2","first-page":"577","article-title":"Activation of coagulation and deep vein thrombosis after bone marrow harvesting and insertion of a Hickman catheter in ABMT patients with malignant lymphoma","volume":"17","author":"Sletnes KE","year":"1996","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04638.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03591.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900801)66:3<515::AID-CNCR2820660319>3.0.CO;2-7"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.1.207"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702675"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(03)00099-9"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.20512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T10:07:40Z","timestamp":1700042860000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.20512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12,20]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1002\/ajh.20512"],"URL":"https:\/\/doi.org\/10.1002\/ajh.20512","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12,20]]}}}