{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:06:24Z","timestamp":1761894384488},"reference-count":51,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T00:00:00Z","timestamp":1156464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Plasma cell dyscrasias are a group of clinically and biochemically diverse disorders of unknown etiology, characterized by the disproportionate proliferation of one or more clones of B cells, and the presence of a structurally and electrophoretically homogeneous (monoclonal) immunoglobulin or polypeptide subunit in serum or urine. The role of splenectomy in the management of plasma cell dyscrasias has not been well defined. Using MEDLINE, the authors searched the English\u2010language published literature from the year 1970 through September 2005 to determine the indications for splenectomy in plasma cell dyscrasias.<\/jats:p><jats:p>A review of the literature in humans and animals supported the idea that the spleen provides a special microenvironment favorable for homing or differentiation of IgM producing B cells, and splenectomy can, at times, lead to remission in Waldenstr\u00f6m's macroglobulinemia. The other reported reasons for splenectomy in plasma cell dyscrasias are hypersplenism\u2010related pancytopenia, control of splenic plasmacytomas, and management of a splenic abscess. Splenic infiltration in primary amyloidosis can be an indication for splenectomy, where removal of a large spleen can also reverse an acquired factor X deficiency. Thus, the spleen can be considered a potential target organ for management of plasma cell dyscrasias, and therapeutic success has been achieved with removal of this organ.<\/jats:p><jats:p>However, splenectomy can be a potentially morbid procedure in patients with plasma cell dyscrasias, and major postoperative complications include infection, hemorrhage, and thrombosis. Am. J. Hematol., 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20736","type":"journal-article","created":{"date-parts":[[2006,8,26]],"date-time":"2006-08-26T02:22:55Z","timestamp":1156558975000},"page":"946-954","source":"Crossref","is-referenced-by-count":11,"title":["Splenectomy in plasma cell dyscrasias: A review of the clinical practice"],"prefix":"10.1002","volume":"81","author":[{"given":"Prashant","family":"Kapoor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekta","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priya","family":"Radhakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulette","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,25]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Diagnosis and Treatment of Multiple Myeloma","author":"Waldenstr\u00f6m J","year":"1970"},{"key":"e_1_2_1_3_2","first-page":"469","article-title":"Myelomatosis and hemolytic anemia. Hemolytic anemia, a rare complication of multiple myeloma, is successfully managed by splenectomy","volume":"62","author":"Friedland M","year":"1979","journal-title":"R I Med J"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1978.tb01086.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830370221"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1182\/blood.V39.6.874.874","article-title":"Macroglobulinemia: An analysis for forty patients","volume":"39","author":"MacKenzie MR","year":"1972","journal-title":"Blood"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830480411"},{"key":"e_1_2_1_8_2","first-page":"155","article-title":"Primary splenic presentation of plasma cell dyscrasia: Report of two cases","volume":"6","author":"Horny HP","year":"1992","journal-title":"Hematol Pathol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02787215"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198710000-00029"},{"key":"e_1_2_1_11_2","first-page":"1996","article-title":"Soluble suppressor factor from the spleens of tumor bearing\u2010mice","volume":"38","author":"Subramanian C","year":"1978","journal-title":"Cancer Res"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000064747"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000085058.63483.7f"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197902223000806"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/71.1.121"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05312.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(74)90626-3"},{"key":"e_1_2_1_18_2","first-page":"71","article-title":"Malignant lymphoma with hairy cells and IgM paraprotein. Splenic homing of secreting cells","volume":"69","author":"Spriano P","year":"1984","journal-title":"Haematologica"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197901)43:1<329::AID-CNCR2820430148>3.0.CO;2-2"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199709051789"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(70)90058-4"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1053\/sonc.2003.50039"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199709253371306"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199803000-00020"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10389"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2005.01125.x"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(98)00509-7"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.6.1885"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830110414"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02183.x"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197707142970211"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198104023041407"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-69-4-787"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197507000-00001"},{"key":"e_1_2_1_35_2","first-page":"665","article-title":"Amyloidosis (AL): Clinical and laboratory features in 229 cases","volume":"58","author":"Kyle RA","year":"1983","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197707142970203"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830030303"},{"key":"e_1_2_1_38_2","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1001\/jama.1974.03240120026014","article-title":"Acquired factor X deficiency: Altered plasma antithrombin activity and association with amyloidosis","volume":"230","author":"Galbraith PA","year":"1974","journal-title":"JAMA"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197911083011907"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)91000-8"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1983.00350030211041"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.1.190"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02667.x"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197906)43:6<2340::AID-CNCR2820430625>3.0.CO;2-M"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(78)80080-6"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199603000-00010"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/3.Supplement_1.S184"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1959.00270020001001"},{"key":"e_1_2_1_49_2","first-page":"129","article-title":"Quantitative antibody studies in man. II. The relation of the level of serum proteins to antibody production","volume":"39","author":"Larson DL","year":"1952","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-41-6-1152"},{"key":"e_1_2_1_51_2","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0889-8588(18)30276-4","article-title":"Hemostatic abnormalities of multiple myeloma and related disorders","volume":"6","author":"Glaspy JA","year":"1999","journal-title":"Hematol Oncol Clin North Am"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gassur.2003.10.014"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.20736","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.20736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T04:25:48Z","timestamp":1700022348000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.20736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,25]]},"references-count":51,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1002\/ajh.20736"],"URL":"https:\/\/doi.org\/10.1002\/ajh.20736","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,25]]}}}