{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T06:55:00Z","timestamp":1700031300028},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,9,5]],"date-time":"2006-09-05T00:00:00Z","timestamp":1157414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It has been suggested that alterations of cell cycle genes probably contribute to the pathogenesis of endemic Burkitt's lymphoma (BL) in addition to c\u2010<jats:italic>MYC<\/jats:italic> translocation. Mutations disrupting the normal nuclear localization signal of the retinoblastoma\u2010related gene <jats:italic>Rb2\/p130<\/jats:italic> have been documented in BL cell lines and primary tumors from endemic areas. The aim of this study was to investigate the involvement of <jats:italic>Rb2\/p130<\/jats:italic> gene in the pathogenesis of sporadic BL in Brazil. DNA samples from 26 pediatric BL tumors and two healthy blood donors were screened by PCR amplification followed by single strand conformation polymorphism analysis of exons 19 and 20 (B domain) and exons 21 and 22 (C\u2010terminus), where most of the point mutations in the <jats:italic>Rb2\/p130<\/jats:italic> gene were identified. No abnormal band shifts were present in the samples analyzed. We concluded that mutations in exons 19\u201322 of the <jats:italic>Rb2\/p130<\/jats:italic> are unlikely to be involved directly in the pathogenesis of sporadic Brazilian BL. Am. J. Hematol., 2007. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20749","type":"journal-article","created":{"date-parts":[[2006,9,5]],"date-time":"2006-09-05T18:59:16Z","timestamp":1157482756000},"page":"238-239","source":"Crossref","is-referenced-by-count":2,"title":["Retinoblastoma\u2010related gene<i>Rb2\/p130<\/i> are rarely mutated in Burkitt's lymphoma from Brazil"],"prefix":"10.1002","volume":"82","author":[{"given":"C.E.","family":"Klumb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.P.S.","family":"Magluta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.M.M.","family":"Rezende","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.G.","family":"Apa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.F.S.","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.C.","family":"Maia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/scbi.1995.0011"},{"key":"e_1_2_1_3_2","first-page":"2215","volume-title":"Cancer: Principles and Practice of Oncology","author":"Dalla\u2010Favera R","year":"2001"},{"key":"e_1_2_1_4_2","first-page":"383","article-title":"Genetic alterations disrupting the nuclear localization of the retinoblastoma\u2010related gene RB2\/p130 in human tumor cell lines and primary tumors","volume":"602","author":"Cinti C","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_1_5_2","first-page":"372","article-title":"Mutations in the retinoblastoma\u2010related gene RB2\/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus\u2010mediated gene transfer","volume":"60","author":"Claudio PP","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_1_6_2","first-page":"8","article-title":"Mutations in the retinoblastoma\u2010related gene RB2\/p130 in primary nasopharyngeal carcinoma","volume":"60","author":"Claudio PP","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203815"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/mp.55.3.153"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2009"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc993"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203244"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.20749","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.20749","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T06:02:00Z","timestamp":1700028120000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.20749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,5]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1002\/ajh.20749"],"URL":"https:\/\/doi.org\/10.1002\/ajh.20749","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,5]]}}}