{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:14:05Z","timestamp":1783538045267,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,9,5]],"date-time":"2006-09-05T00:00:00Z","timestamp":1157414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Regular self\u2010infusion of an activated prothrombin complex concentrate (APCC) has been successfully introduced to a 14\u2010year\u2010old boy with hemophilia A. The child was diagnosed as a neonate, and at age 7 years, developed a high titer (127 BU\/mL) factor VIII inhibitor coincident with a protracted ankle joint bleeding. From age 7\u201310 years, he received on\u2010demand therapy using a prothrombin complex concentrate (PCC), PROPLEX\u2010ST. From age 10\u201314 years, he received prophylaxis with PROPLEX\u2010ST, initiated after an intracranial hemorrhage and coincident anamnestic inhibitor response. Throughout 7\u2010year period of PCC treatment, he experienced recurrent bleeding episodes. Self\u2010prophylaxis with APCC, FEIBA VH [Anti\u2010inhibitor Coagulant Complex] (50 U\/kg\/dose three times per week) using infusion pump was initiated at 14 years of age and has continued for 2 years. There were no bleeding, thrombotic events or other adverse events after initiation of this prophylaxis, and inhibitor levels decreased to 1 BU\/mL. His quality of life was improved, particularly with respect to school. Our long observation proposes a well\u2010disciplined home\u2010based FEIBA prophylaxis in inhibitor\u2010positive hemophiliacs. Am. J. Hematol., 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20751","type":"journal-article","created":{"date-parts":[[2006,9,5]],"date-time":"2006-09-05T18:59:36Z","timestamp":1157482776000},"page":"145-149","source":"Crossref","is-referenced-by-count":11,"title":["Successful self\u2010infusion of activated prothrombin complex concentrate for prophylaxis in a child with a factor VIII inhibitor"],"prefix":"10.1002","volume":"82","author":[{"given":"Shouichi","family":"Ohga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Takada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Suga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,5]]},"reference":[{"issue":"10","key":"e_1_2_1_2_2","first-page":"15","article-title":"Hemophilia. 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