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Group 1 has 50 normal healthy controls, while Groups 2 and 3 each has 50 children who were suffering from SCT and SCD, respectively. Anthropometrics measurement and parameters of physical fitness were assessed in all subjects. All children were also subjected to a 5\u2010min running exercise test on a flat motorized treadmill at speed corresponding to 5 km\/hr. Throughout the test, heart rate was monitored and recoded during exercise and for 10\u2010min during recovery. Blood lactate was measured before and 5 min following the completion of test. The mean values of lean body mass and height were lower in the SCD children (<jats:italic>P<\/jats:italic> &lt; 0.05) compared with the healthy subjects and SCT individuals. Children with SCD exhibited a higher mean value (<jats:italic>P<\/jats:italic> &lt; 0.05) for percent body fat and fat mass than the normal healthy subjects and SCT individuals. Although all groups tolerated well the treadmill exercise protocol, the SCD group exhibited higher (<jats:italic>P<\/jats:italic> &lt; 0.05) mean values of heart rate during exercise than those observed in the SCT and normal control children. In addition, SCD children showed higher serum lactate values before and after treadmill exercise compared to the other groups. Children with SCD exhibit high level of adiposity; low level of fitness and their exercise performance appears to be physiologically more stressful as indicated by heart rate and blood lactate concentration responses. Am. J. Hematol., 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20755","type":"journal-article","created":{"date-parts":[[2006,9,19]],"date-time":"2006-09-19T18:56:52Z","timestamp":1158692212000},"page":"91-97","source":"Crossref","is-referenced-by-count":51,"title":["Physical fitness indices and anthropometrics profiles in schoolchildren with sickle cell trait\/disease"],"prefix":"10.1002","volume":"82","author":[{"given":"Hisham","family":"Moheeb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser A.","family":"Wali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud S.","family":"El\u2010Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07330-3"},{"key":"e_1_2_1_3_2","first-page":"53","article-title":"The irreversibly sickled cell: A perspective","volume":"50","author":"Goodman SR","year":"2004","journal-title":"Cell Mol Biol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17192-4"},{"key":"e_1_2_1_5_2","first-page":"21","article-title":"Sickle cell disease","volume":"10","author":"Meremikwu ME","year":"2003","journal-title":"Clin Evid"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/76.1.218"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(00)90053-2"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1998.274.2.E357"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199606)52:2<96::AID-AJH5>3.0.CO;2-0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/02724936.2000.11748143","article-title":"Cardiovascular function in Omani children with sickle cell anemia","volume":"20","author":"Wali YA","year":"2000","journal-title":"Ann Trop Pediatr"},{"key":"e_1_2_1_11_2","first-page":"1","article-title":"Genetic blood disorders survey in the Sultanate of Oman","volume":"49","author":"Al\u2010Riyami AM","year":"2003","journal-title":"J Trop Pediatr"},{"key":"e_1_2_1_12_2","first-page":"181","article-title":"Exercise and hemoglobin S","volume":"31","author":"Kark JA","year":"1994","journal-title":"Semin Hematol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199805000-00002"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-972842"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.5.1186"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19740060"},{"key":"e_1_2_1_17_2","first-page":"1760","article-title":"Sickle cell trait and sudden death in athletes","volume":"58","author":"Holmes PS","year":"1998","journal-title":"Am Fam Physician"},{"key":"e_1_2_1_18_2","first-page":"1472","article-title":"Sickle cell trait and sudden death in athletes","volume":"276","author":"Kerle KK","year":"1996","journal-title":"J Am Med Assoc"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197002052820607"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/03630269609027928"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1081\/HEM-100104033"},{"key":"e_1_2_1_22_2","unstructured":"el\u2010TayebeeA.Genetic blood disorders in Arab countries. 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