{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:23:58Z","timestamp":1754195038624},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,8,23]],"date-time":"2006-08-23T00:00:00Z","timestamp":1156291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 31\u2010year\u2010old man with hemoglobin SC disease was admitted with acute chest syndrome, treated with antibiotics and ventilator support. His restrained right wrist and hand became swollen and cool, thought due to infiltration of an intravenous line. The hand was elevated, ice packs applied around the clock, and prophylactic low molecular weight heparin given. The arm quickly turned gangrenous. In spite of attempted thrombectomy and red blood cell exchange transfusion, amputation was required. Cold, elevation, and measures that reduce blood flow are known precipitators of sickling and crises. Vasoocclusion of the extremities to the point of gangrene is rarely reported in sickle cell disorders, and this case highlights the dangers of measures limiting blood flow in such patients. Am. J. Hematol., 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20761","type":"journal-article","created":{"date-parts":[[2006,8,23]],"date-time":"2006-08-23T21:47:31Z","timestamp":1156369651000},"page":"53-54","source":"Crossref","is-referenced-by-count":6,"title":["Limb amputation in hemoglobin SC disease after application of ice and elevation"],"prefix":"10.1002","volume":"82","author":[{"given":"Sadia","family":"Saleem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Rice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(91)90029-X"},{"key":"e_1_2_1_3_2","first-page":"311","volume-title":"Sickle Cell Disease: Basic Principles and Clinical Practice","author":"Embury SH","year":"1994"},{"key":"e_1_2_1_4_2","first-page":"404","article-title":"Cold water exposure and vaso\u2010occlusive crises in sickle cell anemia","volume":"118","author":"Linda M","year":"1991","journal-title":"J Pediatr"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106273"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1001\/archinte.1974.00320160071007","article-title":"Rheological aspects of sickle cell disease","volume":"133","author":"Klug PP","year":"1974","journal-title":"Arch Intern Med"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10145"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0940111"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2003.102"},{"key":"e_1_2_1_10_2","first-page":"3","article-title":"Sickle cell anemia with thrombosis and gangrene in all four extremities\u2014A case presentation","volume":"56","author":"Maragos GD","year":"1971","journal-title":"Nebr State Med J"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2005.1.58"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.20761","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.20761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T15:18:21Z","timestamp":1696691901000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.20761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,23]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1002\/ajh.20761"],"URL":"https:\/\/doi.org\/10.1002\/ajh.20761","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,23]]}}}