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Twenty\u2010five patients with newly diagnosed and untreated multiple myeloma (MM), and 22 age\u2010, sex\u2010, and bone mineral density\u2010matched control subjects were enrolled. Levels of MIP\u20101\u03b1, OPN, carboxy\u2010terminal telopeptide of Type\u20101 collagen (C\u2010telopeptide or Ctx), deoxypyridinoline (DPD), Type\u20101 collagen propeptide (T1Pro), and bone\u2010specific alkaline phosphatase (BALP) were assessed in both groups. Twenty\u2010two of the patients had bone involvement documented by skeletal surveys and lumbar spinal magnetic resonance imaging. Levels of serum Ctx, OPN, MIP\u20101\u03b1, and urine DPD were significantly higher in MM patients with bone disease than in controls (<jats:italic>P<\/jats:italic> &lt; 0.01). Serum Ctx levels were elevated in 90.9% of patients with MM and 40.9% of controls (<jats:italic>P<\/jats:italic> &lt; 0.001). Urine DPD levels were elevated in 90.4% of the patients and 31.8% of the controls (<jats:italic>P<\/jats:italic> &lt; 0.001). The serum OPN and MIP\u20101\u03b1 levels of the patients were significantly correlated with \u03b22\u2010microglobulin and lactate dehydrogenase levels (<jats:italic>P<\/jats:italic> &lt; 0.05). Our study indicates that Ctx and DPD are sensitive markers of bone disease in MM, and higher than normal values suggest presence of bone disease rather than benign osteoporosis in MM. The utility of OPN and MIP\u20101\u03b1 needs to be further investigated. Am. J. Hematol., 2007. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20794","type":"journal-article","created":{"date-parts":[[2006,10,4]],"date-time":"2006-10-04T18:00:39Z","timestamp":1159984839000},"page":"185-191","source":"Crossref","is-referenced-by-count":25,"title":["Biochemical markers of bone turnover in diagnosis of myeloma bone 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