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These patients have 60\u201365% Hb S, similar to the percent Hb S in patients with Hb S\/\u03b2<jats:sup>+<\/jats:sup>\u2010thalassemia. Their hematological features and clinical course appear to parallel those of Hb S\/\u03b2<jats:sup>+<\/jats:sup>\u2010thalassemia. Patients have variable levels of anemia, and some develop clinical complications. With population migrations and increasing racial intermarriages, Hb SE disease is expected to be encountered more often around the globe. Patients with Hb SE disease should be followed and managed in a similar fashion as those with Hb S\/\u03b2<jats:sup>+<\/jats:sup>\u2010thalassemia, and treated appropriately when they develop sickling\u2010related symptoms and complications. Am. J. Hematol., 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20847","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T08:30:29Z","timestamp":1170491429000},"page":"643-649","source":"Crossref","is-referenced-by-count":45,"title":["Hemoglobin SE disease\u2014A concise review"],"prefix":"10.1002","volume":"82","author":[{"given":"David","family":"Masiello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew M.","family":"Heeney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeboye H.","family":"Adewoye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn H.","family":"Eung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Yuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin H.","family":"Steinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David. 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