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The major clinical problem associated with HIT is thrombosis. Early detection and institution of alternative, non\u2010heparin anticoagulation are important. We report a patient with HIT associated with use of therapeutic\u2010dose unfractionated heparin in whom immune sensitization to heparin was triggered by two 500\u2010unit exposure to UFH associated with intravascular catheter flushing for antineoplastic chemotherapy in a patient with colon adenocarcinoma. Am. J. Hematol. 82: 2007. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20849","type":"journal-article","created":{"date-parts":[[2006,12,18]],"date-time":"2006-12-18T19:47:35Z","timestamp":1166471255000},"page":"652-655","source":"Crossref","is-referenced-by-count":30,"title":["Immune heparin\u2010induced thrombocytopenia resulting from preceding exposure to heparin catheter flushes"],"prefix":"10.1002","volume":"82","author":[{"given":"Alaa A.","family":"Muslimani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basma","family":"Ricaurte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed A.","family":"Daw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.3_suppl.311S"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104263441704"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1089"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH03-07-0454"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.10.3300"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005200050303"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505183322003"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000110187.16764.9A"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1999.00527.x"},{"key":"e_1_2_1_11_2","first-page":"470","article-title":"Heparin\u2010induced thrombocytopenia and thromboembolism in the postoperative period","volume":"103","author":"Walter ER","year":"1988","journal-title":"Surgery"},{"issue":"1","key":"e_1_2_1_12_2","first-page":"12","article-title":"A mouse model for heparin\u2010induced thrombocytopenia","volume":"36","author":"Blank M","year":"1999","journal-title":"Semin Hematol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V67.1.27.27"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/104.6.611"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(96)00258-6"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000119426.34340.E2"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116987"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1544"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1055\/s-0037-1615945","article-title":"Heparin\u2010induced thrombocytopenia: Yet another treatment paradox?","volume":"85","author":"Warkentin TE","year":"2001","journal-title":"Thromb Haemost"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00124-2"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04334.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-006-5571-z"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G738"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023238915316"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.20849","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.20849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T05:55:39Z","timestamp":1700027739000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.20849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,18]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["10.1002\/ajh.20849"],"URL":"https:\/\/doi.org\/10.1002\/ajh.20849","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,18]]}}}