{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:09:06Z","timestamp":1791410946002,"version":"4.3.3"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,3,20]],"date-time":"2007-03-20T00:00:00Z","timestamp":1174348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary adrenal lymphoma (PAL) is very rare; the majority of cases reported previously were of B\u2010cell origin. We report a rare case of primary adrenal adult T\u2010cell leukemia\/lymphoma (primary adrenal ATLL). ATLL is a highly aggressive T\u2010cell type non\u2010Hodgkin's lymphoma and etiologically associated with human T\u2010cell lymphotropic virus 1 (HTLV\u20101). Most ATLL patients present with leukemia and widespread lymphadenopathy. A 37\u2010year\u2010old Japanese woman presented with back pain in January 2004. Examination showed no peripheral lymphadenopathy, circulating lymphoma cells, hepatosplenomegaly, and skin lesions. Imaging studies demonstrated large adrenal masses bilaterally. Subsequently, she underwent open adrenal biopsy and pathological diagnosis was confirmed as T\u2010cell lymphoma. The serum antibody to HTLV\u20101 was positive. Southern blot analysis detected monoclonal integration of proviral DNA of HTLV\u20101 into host genome in the biopsy specimen. The diagnosis of ATLL arising in adrenal glands was established. Despite repeated systemic chemotherapy, the patient died of progressive disease in December 2004. ATLL could primarily involve the adrenal gland and this disease entity should be included in the differential diagnosis of adrenal mass lesions. Am. J. Hematol., 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.20856","type":"journal-article","created":{"date-parts":[[2007,3,21]],"date-time":"2007-03-21T09:16:33Z","timestamp":1174468593000},"page":"748-752","source":"Crossref","is-referenced-by-count":16,"title":["Primary adrenal adult T\u2010cell leukemia\/lymphoma: A case report and review of the 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