{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:33:03Z","timestamp":1789162383968,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,9,17]],"date-time":"2007-09-17T00:00:00Z","timestamp":1189987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatosplenic T\u2010cell lymphoma (HSTL) is an aggressive lymphoma. In post\u2010transplant immunosuppressed patients, HSTL is usually rapidly fatal. We report successful treatment of post\u2010transplant HSTL in a 50\u2010year\u2010old renal allograft recipient by reducing immunosuppression and using intensive chemotherapy consisting of alternating cycles of HyperCVAD (cyclophosphamide, vincristine, doxorubicin, and dexamethasone) and MTX\/HiDAC (methotrexate, Ara\u2010C). Remission is ongoing at 8+ years. Literature review identified another 20 cases of HSTL in solid organ transplant recipients: median survival was 4 months; no other patients survived beyond 12 months. Bone marrow involvement was universal, but changes were often subtle: 6 of 12 cases had nondiagnostic examinations earlier on. High index of suspicion may lead to more timely diagnosis of this uncommon form of post\u2010transplant lymphoproliferative disorder, and treatment with intensive chemotherapy such as HyperCVAD may be curative. Am. J. Hematol., 2008. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21062","type":"journal-article","created":{"date-parts":[[2007,9,17]],"date-time":"2007-09-17T16:48:15Z","timestamp":1190047695000},"page":"330-333","source":"Crossref","is-referenced-by-count":26,"title":["Post\u2010transplant hepatosplenic T\u2010cell lymphoma successfully treated with hyperCVAD regimen"],"prefix":"10.1002","volume":"83","author":[{"given":"Siok\u2010Keen","family":"Tey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula V.","family":"Marlton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmel M.","family":"Hawley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devinder 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