{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T15:10:15Z","timestamp":1737817815635,"version":"3.33.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,1,10]],"date-time":"2008-01-10T00:00:00Z","timestamp":1199923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CD5\u2010negative chronic B cell lymphoproliferative disorders in leukemic phase (B\u2010CLPD) are heterogeneous and relatively uncommon pathologies that often lack a histopathological definition because of the absence of accessible pathological tissue. We describe the clinical features and evolution\u2010related variables of 156 patients with CD5\/CD10\u2010negative B\u2010CLPD (median age 66 years, range 25\u201386). The median follow\u2010up was 51 months (range 6\u2013216), and overall 3\u2010 and 5\u2010year survival was respectively 87 and 76%; 50 patients needed therapy at diagnosis, 56 during follow\u2010up, and 50 remained untreated until the last control. A combined clinical, histological, cytomorphological, immunophenotypical, and cytogenetic diagnostic approach allowed the complete classification of only a minority of patients as being affected by splenic marginal zone or lymphoplasmacytic lymphoma; the majority of cases remained unclassifiable. Multivariate analysis showed that the clinicohematological variables adversely related to overall survival were serum LDH levels and age, whereas high serum LDH levels, hemoglobin levels of &lt;11 g\/dl, and splenomegaly related to treatment\u2010free time (in \u201cwait and see\u201d cases); only splenomegaly related to time to progression (in treated patients). In conclusion, our retrospective study describes the clinical features and variables related to evolution in a large group of patients with CD5\/CD10\u2010negative chronic B\u2010cell lymphoid leukemias and underlines the fact that a probable lymphoplasmacytic or marginal zone normal cell origin can be supposed in such leukemic forms, but never surely demonstrated. Am. J. Hematol. 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21065","type":"journal-article","created":{"date-parts":[[2008,1,11]],"date-time":"2008-01-11T01:46:39Z","timestamp":1200015999000},"page":"349-354","source":"Crossref","is-referenced-by-count":23,"title":["A multicenter retrospective clinical study of CD5\/CD10\u2010negative chronic B cell leukemias"],"prefix":"10.1002","volume":"83","author":[{"given":"Maria","family":"Goldaniga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ferrario","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Cortelazzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Guffanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enzo","family":"Pavone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achille","family":"Ambrosetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Marcheselli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Luminari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilla","family":"Cro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Federico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Lambertenghi Deliliers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Baldini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,10]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.42.6.567"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.12.3835"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190600727939"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190600758660"},{"key":"e_1_2_1_6_2","first-page":"127","volume-title":"Tumours of Haematopoietic and Lymphoid Tissues","author":"Muller\u2010Hermelink HK","year":"2001"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05548.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402737"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/111.1.123"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1182\/blood.V78.7.1795.1795","article-title":"Prognostic importance of flow cytometric immunophenotyping of 540 consecutive patients with B\u2010cell chronic lymphocytic leukaemia","volume":"78","author":"Geisler CH","year":"1991","journal-title":"Blood"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/111.4.477"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10044"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10222"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1182\/blood.V83.9.2602.2602","article-title":"Surface phenotype and Ig heavy\u2010chain gene usage in chronic B\u2010cell leukemias: Expression of myelomonocytic surface markers in CD5\u2010 chronic B\u2010cell leukaemia","volume":"83","author":"Ikematsu W","year":"1994","journal-title":"Blood"},{"key":"e_1_2_1_15_2","first-page":"451","article-title":"CD5 negative lymphocytosis mimicking typical B\u2010chronic lymphocytic leukaemia. 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