{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T04:46:15Z","timestamp":1781412375707,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,1,8]],"date-time":"2008-01-08T00:00:00Z","timestamp":1199750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several recent studies have suggested that an association exists between <jats:italic>Helicobacter pylori<\/jats:italic> (HP) eradication and improvement in platelet count in a significant proportion of patients with idiopathic thrombocytopenic purpura (ITP). In this controlled study, we prospectively examined adult patients with chronic ITP for HP infection, and assessed the effect of HP eradication on platelet count. One hundred forty\u2010two consecutive Iranian patients with chronic ITP were assessed. Those who met the criteria and had platelet counts &gt;30 \u00d7 10<jats:sup>9<\/jats:sup>\/L within the medication\u2010free screening month were enrolled (<jats:italic>n<\/jats:italic> = 129; 66 females; mean age, 29.2 \u00b1 7.0 years). HP\u2010positive patients received a 2\u2010week course of triple HP eradication therapy (i.e., amoxicillin, clarithromycin, and omeprazole) and were followed for 48 weeks. An ITP response was defined as a platelet count of &gt;100 \u00d7 10<jats:sup>9<\/jats:sup>\/L 24 weeks after treatment, together with an increase in the platelet count &gt;30 \u00d7 10<jats:sup>9<\/jats:sup>\/L over the baseline value. HP infection was detected in 79 (61%) patients. HP\u2010positive patients were significantly older than HP\u2010negative subjects (<jats:italic>P<\/jats:italic> = 0.018). HP eradication was successful in 87% (62\/71) of those who completed the eradication therapy. Whereas 48% (30\/62) of HP\u2010eradicated patients showed an ITP response, no HP\u2010negative patient had an ITP response. The ITP response persisted for 48 weeks in 93% (28\/30) of the responders. The ITP responders had a shorter disease duration than the nonresponders (<jats:italic>P<\/jats:italic> = 0.002). The management of mild\u2010to\u2010moderate chronic ITP in Iranian patients, especially those with a recent onset of disease, should include an investigation for and eradication of infection with HP. Am. J. Hematol., 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21125","type":"journal-article","created":{"date-parts":[[2008,1,8]],"date-time":"2008-01-08T22:46:53Z","timestamp":1199832413000},"page":"376-381","source":"Crossref","is-referenced-by-count":39,"title":["Effect of eradication of <i>Helicobacter pylori<\/i> on platelet recovery in patients with chronic idiopathic thrombocytopenic purpura: A controlled 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