{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:56:20Z","timestamp":1761807380980},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,1,7]],"date-time":"2008-01-07T00:00:00Z","timestamp":1199664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with myeloproliferative disorders (MPD) are prone to develop thrombotic complications and thus frequently receive heparin. Surprisingly heparin\u2010induced thrombocytopenia (HIT) has been rarely reported in MPD and is potentially under\u2010diagnosed due to the relatively high platelet count. We report three patients with MPD who developed HIT; all presented with a relative fall of platelet counts (although without an absolute thrombocytopenia), thrombosis or skin necrosis and a positive test for HIT antibodies (particle gel immunoassay). Risk factors for developing HIT in our patients were exposure to unfractionated heparin, a recent surgical procedure and female gender. We review the literature on HIT in MPD and discuss the diagnosis of HIT in the absence of an absolute thrombocytopenia. Am. J. Hematol., 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21128","type":"journal-article","created":{"date-parts":[[2008,1,7]],"date-time":"2008-01-07T22:49:25Z","timestamp":1199746165000},"page":"420-423","source":"Crossref","is-referenced-by-count":22,"title":["Heparin\u2010induced thrombocytopenia in myeloproliferative disorders: A rare or under\u2010diagnosed complication?"],"prefix":"10.1002","volume":"83","author":[{"given":"Galia","family":"Spectre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yossi","family":"Kalish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Schliamser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Varon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2005.07.012"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505183322003"},{"key":"e_1_2_1_4_2","first-page":"26","article-title":"Heparin\u2010induced thrombocytopenia","volume":"60","author":"Demasi R","year":"1994","journal-title":"Am Surg"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199304000-00003"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000110187.16764.9A"},{"issue":"1","key":"e_1_2_1_7_2","first-page":"69","article-title":"Decreased prevalence of heparin\u2010induced thrombocytopenia with low\u2010molecular\u2010weight heparin and related drugs","author":"Walenga JM","year":"2004","journal-title":"Semin Thromb Hemost"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-0912"},{"key":"e_1_2_1_9_2","first-page":"9","article-title":"Clinical presentation of heparin induced thrombocytopenia","volume":"35","author":"Warkentin TE","year":"1998","journal-title":"Semin Hematol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-9-199511010-00003"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.1.300-a"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200010000-00011"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8652(200012)65:4<331::AID-AJH23>3.0.CO;2-2"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000204883"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.43.587"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.10.1503"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.13.4261"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-135-7-200110020-00009"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200305000-00003"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1055\/s-0037-1614218","article-title":"Factor V Leiden and thrombotic complications in heparin\u2010induced thrombocytopenia","volume":"79","author":"Lee DH","year":"1998","journal-title":"Thromb Haemost"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.20.2518"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(96)00407-2"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200301000-00020"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-11-012450"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2006.1.408"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.21128","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.21128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T12:38:22Z","timestamp":1696682302000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.21128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,7]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1002\/ajh.21128"],"URL":"https:\/\/doi.org\/10.1002\/ajh.21128","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,7]]}}}