{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:11:08Z","timestamp":1761894668534},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,2,13]],"date-time":"2008-02-13T00:00:00Z","timestamp":1202860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral T\u2010cell lymphoma (PTCL) is an aggressive form of non\u2010Hodgkin's lymphoma (NHL), associated with poor prognosis and without standard approach to treatment. Denileukin diftitox (Ontak\u00ae) is a synthetic fusion protein combining the receptor\u2010binding domain of interleukin\u20102 to the enzymatically active portion of diphtheria toxin. While approved for the treatment of cutaneous T\u2010cell lymphoma, it has demonstrated activity in non\u2010Hodgkin's lymphomas of both T\u2010cell and B\u2010cell origin. This report documents the first case of de novo maintenance therapy with denileukin diftitox sustaining an ongoing complete response at the molecular level for 2 years in a patient with PTCL. Am. J. Hematol. 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21177","type":"journal-article","created":{"date-parts":[[2008,2,13]],"date-time":"2008-02-13T20:16:24Z","timestamp":1202933784000},"page":"596-598","source":"Crossref","is-referenced-by-count":13,"title":["De novo maintenance therapy with denileukin diftitox (Ontak\u00ae) in a patient with peripheral T\u2010cell lymphoma is associated with prolonged remission"],"prefix":"10.1002","volume":"83","author":[{"given":"Bryan Y.","family":"Wong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yupo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Fitzwilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam H.","family":"Dang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,3,27]]},"reference":[{"volume-title":"Cancer Facts and Figures","year":"2007","author":"American Cancer Society","key":"e_1_2_1_2_2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20999"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/07357900701360096"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(03)00119-9"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190412331272749"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh471"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704392"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.2.376"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06457.x"},{"issue":"10","key":"e_1_2_1_11_2","first-page":"3555","article-title":"A phase II study of DT fusion protein denileukin diftitox in patients with fludarabine\u2010refractory chronic lymphocytic leukemia","volume":"9","author":"Frankel AE","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.03.071"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0028"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2061"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1375.002"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.17.3766"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.21177","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.21177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T10:22:19Z","timestamp":1699957339000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.21177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,27]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1002\/ajh.21177"],"URL":"https:\/\/doi.org\/10.1002\/ajh.21177","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"type":"print","value":"0361-8609"},{"type":"electronic","value":"1096-8652"}],"subject":[],"published":{"date-parts":[[2008,3,27]]}}}