{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:41:42Z","timestamp":1792644102365,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,5,16]],"date-time":"2008-05-16T00:00:00Z","timestamp":1210896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe monozygotic female twins discordant for hemophilia A, born to a carrier mother and normal father. Affected twin A presented at age 1 year with excessive bruising and factor VIII procoagulant activity (FVIII:C) of less than 1% of normal. Twin B is an asymptomatic carrier with FVIII:C level of 42%. Peripheral blood DNA was tested for X\u2010chromosome inactivation (methylation) patterns of the X\u2010linked human androgen receptor gene, comparing the twins' patterns to parental. Twin A showed nonrandom inactivation skewed toward the paternal X, whereas twin B showed random X\u2010inactivation. This is the first reported case of discordance for hemophilia A between female monozygotic twins. Am. J. Hematol., 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21219","type":"journal-article","created":{"date-parts":[[2008,5,16]],"date-time":"2008-05-16T18:19:05Z","timestamp":1210961945000},"page":"778-780","source":"Crossref","is-referenced-by-count":36,"title":["Female monozygotic twins discordant for hemophilia A due to nonrandom X\u2010chromosome inactivation"],"prefix":"10.1002","volume":"83","author":[{"given":"Carolyn M.","family":"Bennett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Boye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellis J.","family":"Neufeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,21]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614406"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1055\/s-0038-1649265","article-title":"Inherited bleeding syndromes in Iraq","volume":"37","author":"Al\u2010Mondhiry HA","year":"1977","journal-title":"Thromb Haemost"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02105.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05213.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1999.00352.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2003.00704.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.13.4373"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0277"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201799"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.37.8.603"},{"key":"e_1_2_1_12_2","first-page":"672","article-title":"Skewed X inactivation in a female MZ twin results in Duchenne muscular dystrophy","volume":"46","author":"Richards CS","year":"1990","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_13_2","first-page":"291","article-title":"Different patterns of X inactivation in MZ twins discordant for red\u2010green color\u2010vision deficiency","volume":"51","author":"Jorgensen AL","year":"1992","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2004.11.009"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320440625"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/302502"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/301978"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11432"},{"key":"e_1_2_1_19_2","first-page":"1229","article-title":"Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen\u2010receptor gene correlates with X chromosome inactivation","volume":"51","author":"Allen RC","year":"1992","journal-title":"Am J Hum Genet"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.21219","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.21219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T14:53:34Z","timestamp":1699973614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.21219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,21]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1002\/ajh.21219"],"URL":"https:\/\/doi.org\/10.1002\/ajh.21219","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,21]]}}}