{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:03:50Z","timestamp":1787169830516,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,7,22]],"date-time":"2008-07-22T00:00:00Z","timestamp":1216684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Overexpression of P\u2010glycoprotein (P\u2010gp) has been identified by a variety of methods in NK cells and NK malignancies. The aim of this study was to determine the clinical significance of P\u2010gp in previously untreated extranodal NK\/T\u2010cell lymphoma, nasal type. Tumor specimens from 30 patients initially treated with CHOP or CHOP\u2010based chemotherapy were examined by immunohistochemistry using JSB\u20101, a monoclonal antibody recognizing the intracellular epitope of P\u2010gp molecule. Twenty cases (67%) were positive for P\u2010gp expression. The complete response rate achieved in P\u2010gp positive patients was significantly lower than in P\u2010gp negative ones (20% vs. 60%,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.045). With a median follow\u2010up of 25 months, the 2\u2010year progression\u2010free survival (PFS) and overall survival (OS) rates for all patients were 66 and 69%, respectively. Compared with both PFS and OS rates of P\u2010gp positive patients, those of P\u2010gp negative patients showed a trend of benefit that did not reach statistical significance for borderline\n                    <jats:italic>P<\/jats:italic>\n                    values (PFS: 90% vs. 54%,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.1057; OS: 90% vs. 61%,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.2028). Our results suggest that P\u2010gp expression is related with poor treatment outcomes of extranodal NK\/T\u2010cell lymphoma, nasal type. Am. J. Hematol., 2008. \u00a9 2008 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ajh.21256","type":"journal-article","created":{"date-parts":[[2008,7,22]],"date-time":"2008-07-22T15:37:14Z","timestamp":1216741034000},"page":"795-799","source":"Crossref","is-referenced-by-count":78,"title":["Immunohistochemical expression and clinical significance of P\u2010glycoprotein in previously untreated extranodal NK\/T\u2010cell lymphoma, nasal type"],"prefix":"10.1002","volume":"83","author":[{"given":"Biyun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Qiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,8,28]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"204","volume-title":"Tumours of Haematopoietic and Lymphoid Tissues. World Health Organization Classification of Tumours","author":"Chan JK","year":"2001"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001115)89:10<2106::AID-CNCR11>3.0.CO;2-G"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800157"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.10.2688.2688"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.1384"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011144911781"},{"key":"e_1_2_1_8_2","first-page":"427","article-title":"The effect of pre\u2010irradiation dose intense CHOP on anthracyline resistance in localized nasal NK\/T\u2010cell lymphoma","volume":"91","author":"Lee SH","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.2573"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.06.088"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.53.082901.103929"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-200111000-00008"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.9.2215.2215"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(96)00055-X"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(94)90209-7"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19951201)76:11<2351::AID-CNCR2820761125>3.0.CO;2-1"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.8.2966"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.2.599"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-2056"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2001.01214.x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190410001693524"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a057676"},{"key":"e_1_2_1_23_2","first-page":"3010","article-title":"Methods to detect P\u2010glycoprotein\u2010associated multidrug resistance in patients' tumors: Consensus recommendations","volume":"56","author":"Beck WT","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.7.619"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2000.00689.x"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190600562823"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.11.020"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000086984"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.21256","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.21256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T09:53:59Z","timestamp":1699955639000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.21256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,28]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1002\/ajh.21256"],"URL":"https:\/\/doi.org\/10.1002\/ajh.21256","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,28]]}}}