{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T15:20:58Z","timestamp":1767972058796,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T00:00:00Z","timestamp":1221782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Philadelphia (Ph) chromosome is characteristic of chronic myelogenous leukemia (CML), but it is also the most frequent cytogenetic abnormality in precursor B\u2010lymphoblastic leukemia (ALL) of adults. The vast majority of CML patients have a BCR\u2010ABL translocation that yields a 210 kD (p210) oncoprotein, whereas adult Ph\u2010positive ALL cases can present with either a p190 or a p210 oncoprotein, or both. Considering that 30% of the patients with CML that progress to blast crisis will have a lymphoblastic presentation, adults presenting with a p210 ALL may have either a de novo ALL or CML presenting for the first time in lymphoblastic phase. To identify the distinguishing features, cases of p190\u2010ALL, p210\u2010ALL, and lymphoblastic CML were compared. In spite of significant overlap between the three entities, a number of features were found to aid in their differentiation. p210\u2010ALL patients present at a younger age with blasts that frequently show loss of expression of CD34, whereas p190\u2010ALL patients present with marked increase in peripheral blast percentage. Interestingly, bone marrow findings characteristic of a myeloproliferative disorder are specific, but are not sensitive for lymphoblastic CML. This study suggests that despite the similarities between these leukemias, p190\u2010ALL, p210\u2010ALL, and lymphoblastic phase CML likely represent three distinct diseases. Am. J. Hematol., 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21291","type":"journal-article","created":{"date-parts":[[2008,9,20]],"date-time":"2008-09-20T04:58:14Z","timestamp":1221886694000},"page":"901-907","source":"Crossref","is-referenced-by-count":10,"title":["The spectrum of adult B\u2010lymphoid leukemias with BCR\u2010ABL: Molecular diagnostic, cytogenetic, and clinical laboratory perspectives"],"prefix":"10.1002","volume":"83","author":[{"given":"Jeffery M.","family":"Klco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friederike H.","family":"Kreisel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara A.","family":"Zehnbauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashikant","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjum","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Frater","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1309\/B4NVER1AJJ84CTUU"},{"key":"e_1_2_1_3_2","first-page":"665","article-title":"Molecular and phenotypic spectrum of de novo Philadelphia positive acute leukemia","volume":"4","author":"Lim LC","year":"1999","journal-title":"Int J Mol Med"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2003.11.003"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206094"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2147"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-10-200305200-00010"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10490"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb08048.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(93)90122-6"},{"key":"e_1_2_1_11_2","first-page":"795","article-title":"Lineage involvement by BCR\/ABL in Ph+ lymphoblastic leukemias: Chronic myelogenous leukemia presenting in lymphoid blast vs Ph+ acute lymphoblastic leukemia","volume":"10","author":"Anastasi J","year":"1996","journal-title":"Leukemia"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400986"},{"key":"e_1_2_1_13_2","first-page":"423","article-title":"Philadelphia chromosome\u2010positive acute myeloid leukemia: Cytoimmunologic and cytogenetic feature","volume":"81","author":"Cuneo AFA","year":"1996","journal-title":"Haematologica"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000084448"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00542.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(94)90109-0"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(93)90206-2"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.9.1399"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2408149"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1182\/blood.V95.9.2913.009k32_2913_2921","article-title":"Analysis of the biologic properties of p230 Bcr\u2010Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr\u2010Abl tyrosine kinases","volume":"95","author":"Quackenbush RC","year":"2000","journal-title":"Blood"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1253"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.5.1536"},{"key":"e_1_2_1_23_2","first-page":"377","article-title":"The role of BCR\/ABL isoforms in the presentation and outcome of patients with Philadelphia\u2010positive acute lymphoblastic leukemia: A seven\u2010year update of the GIMEMA 0496 trial","volume":"91","author":"Cimino G","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-0734.2002.00066.x"},{"key":"e_1_2_1_25_2","first-page":"365","article-title":"Kinase inhibitors in chronic myelogenous leukemia","volume":"4","author":"Quintas\u2010Cardama A","year":"2006","journal-title":"Clin Adv Hematol Oncol"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22881"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct071828"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2324"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.15.5698"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.d01-1786.x"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.21291","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.21291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T14:42:10Z","timestamp":1699972930000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.21291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,17]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["10.1002\/ajh.21291"],"URL":"https:\/\/doi.org\/10.1002\/ajh.21291","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,17]]}}}