{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T09:46:41Z","timestamp":1764841601691},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,10,8]],"date-time":"2008-10-08T00:00:00Z","timestamp":1223424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Early lymphocyte recovery (ELR) after autologous peripheral hematopoietic stem cell transplantation (ASCT) is an independent predictor for survival in patients with hematological and non\u2010hematological cancers. Sixty\u2010five ASCT for hematological cancers were retrospectively analyzed to identify the factors associated with ELR and to assess the impact of different mobilization regimens on the pre\u2010collection absolute lymphocyte count (ALC). The CD8+ lymphocyte dose in the autograft and the pre\u2010mobilization ALC were independently associated with ELR (<jats:italic>P<\/jats:italic> &lt; 0.001 and <jats:italic>P<\/jats:italic> = 0.008, respectively). CD8+ lymphocyte doses higher than 0.1 \u00d7 10<jats:sup>9<\/jats:sup>\/kg were strongly associated with ELR [<jats:italic>P<\/jats:italic> &lt; 0.001, odds ratio 25.22, 95% confidence interval (CI) 4.98\u2013127.69] and this cutoff may be used to predict ELR (<jats:italic>P<\/jats:italic> = 0.001, area under the curve 0.75, 95% CI 0.62\u20130.88). Mobilization with granulocyte colony\u2010stimulating factor (G\u2010CSF) alone, the pre\u2010collection ALC and the number of apheresis sessions were independently associated with the CD8+ lymphocyte dose (<jats:italic>P<\/jats:italic> = 0.04, <jats:italic>P<\/jats:italic> = 0.001, and <jats:italic>P<\/jats:italic> &lt; 0.001, respectively). The number of aphereses was the variable with the strongest correlation to the CD8+ lymphocyte dose (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub> = 0.68, <jats:italic>P<\/jats:italic> &lt; 0.001). Median pre\u2010mobilization ALC was higher than pre\u2010collection ALC in the subgroup of patients without ELR mobilized with chemotherapy followed by G\u2010CSF (1090 vs. 758 lymphocytes\/\u03bcL; <jats:italic>P<\/jats:italic> &lt; 0.001). This reduction was not significant in the subgroup with ELR mobilized with chemotherapy plus G\u2010CSF (1920 vs. 1539\/\u03bcL, respectively; <jats:italic>P<\/jats:italic> = 0.23). These results suggest that the CD8+ lymphocyte dose in the autograft is critical for ELR after ASCT and also demonstrates that mobilization with chemotherapy followed by G\u2010CSF significantly decreases the pre\u2010collection ALC, especially in patients with low pre\u2010mobilization ALC. Am. J. Hematol, 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21314","type":"journal-article","created":{"date-parts":[[2008,10,8]],"date-time":"2008-10-08T20:58:19Z","timestamp":1223499499000},"page":"21-28","source":"Crossref","is-referenced-by-count":22,"title":["High CD8+ lymphocyte dose in the autograft predicts early absolute lymphocyte count recovery after peripheral hematopoietic stem cell transplantation"],"prefix":"10.1002","volume":"84","author":[{"given":"Elias Hallack","family":"Atta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Mello","family":"de Azevedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Maiolino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia J\u00falia Bruzzi Porto","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Maria Pati\u00f1o","family":"Sarcinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia","family":"de Alvarenga M\u00e1ximo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera L\u00facia Neves","family":"Marra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,11,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"6","article-title":"Part I\u2010CIBMTR summary slides, 2007","volume":"13","author":"Pasquini M","year":"2007","journal-title":"CIBMTR 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