{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:03:33Z","timestamp":1788919413234,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,11,3]],"date-time":"2008-11-03T00:00:00Z","timestamp":1225670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serum B\u2010lymphocyte stimulator (BLyS) levels are elevated in a subset of non\u2010Hodgkin lymphoma (NHL) patients, particularly those with a family history of B\u2010cell malignancies or a polymorphism in the BLyS gene. BLyS promotes growth of malignant B\u2010cells and increased serum BLyS levels are associated with a poor clinical outcome. In this study, BLyS levels were measured before and after 4 weekly doses of rituximab in 30 patients with previously untreated follicular Grade 1 NHL. A significant increase was seen in the serum levels of BLyS (<jats:italic>P<\/jats:italic> = 0.0001) after rituximab therapy. The increase was independent of genetic variability in the BLyS gene. Am. J. Hematol., 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21328","type":"journal-article","created":{"date-parts":[[2008,11,3]],"date-time":"2008-11-03T16:31:35Z","timestamp":1225729895000},"page":"71-73","source":"Crossref","is-referenced-by-count":15,"title":["Serum BLyS levels increase after rituximab as initial therapy in patients with follicular grade 1 non\u2010Hodgkin lymphoma"],"prefix":"10.1002","volume":"84","author":[{"given":"Stephen M.","family":"Ansell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne J.","family":"Novak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Ziesmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy","family":"Price\u2010Troska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betsy","family":"LaPlant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey R.","family":"Dillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Witzig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri844"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00566-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.11.1747"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1061965"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-02-0558"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0762"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.7938"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.1.101"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.08.674"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.12.052"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/sonc.2003.50023"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.060772"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2076"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21650"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22603"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/35010115"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00183-2"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"173A","DOI":"10.1182\/blood.V110.11.564.564","article-title":"Polymorphisms in the BLyS gene are associated with an increased risk of developing B\u2010Cell non\u2010Hodgkin lymphoma [Abstract]","volume":"110","author":"Novak AJ","year":"2007","journal-title":"Blood"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.3268"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406111101"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2006.02377.x"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10317"},{"key":"e_1_2_1_24_2","article-title":"Increased serum BAFF (B\u2010cell activating factor of the TNF family) level is a peculiar feature associated with familial chronic lymphocytic leukemia","author":"Molica S","year":"2008","journal-title":"Leuk Res"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.21328","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.21328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T03:21:08Z","timestamp":1699932068000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.21328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1002\/ajh.21328"],"URL":"https:\/\/doi.org\/10.1002\/ajh.21328","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}