{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T09:06:59Z","timestamp":1764493619504},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T00:00:00Z","timestamp":1226275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cold agglutinin disease occurring with cryoglobulinemia is a rare occurrence. Here, we report a patient with mixed cryoglobulinemia that was treated with rituximab and, after response, developed an anti\u2010Pr cold agglutinin that manifested with hemolysis and microvascular occlusion causing mesenteric ischemia and cerebral infarction. Unlike previous reports of patients with cryoglobulinemia and cold agglutinin disease, our patient did not have a detectable cryoprecipitate when his cold agglutinin manifested. Am. J. Hematol, 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21330","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T16:54:36Z","timestamp":1226336076000},"page":"120-122","source":"Crossref","is-referenced-by-count":27,"title":["Catastrophic multiple organ ischemia due to an anti\u2010Pr cold agglutinin developing in a patient with mixed cryoglobulinemia after treatment with rituximab"],"prefix":"10.1002","volume":"84","author":[{"given":"Joshua","family":"Ruch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"McMahon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn","family":"Ramsey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hau C.","family":"Kwaan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2005.n.019"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/10245330701445392"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.1.4"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(74)90852-3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02054020"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2001.00824.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(66)90200-2"},{"key":"e_1_2_1_9_2","first-page":"484","article-title":"Central nervous system involvement in hepatitis C virus cryoglobulinemia vasculitis: A multicenter case\u2010control study using magnetic resonance imaging and neuropsychological tests","volume":"32","author":"Casato M","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)63005-X"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2856"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2006.1.19"},{"key":"e_1_2_1_13_2","first-page":"410","article-title":"Red cell destruction in cold agglutinin disease","volume":"21","author":"Zilow G","year":"1994","journal-title":"Infusionsther Transfusionsmed"},{"key":"e_1_2_1_14_2","volume-title":"Hemolytic anemia resulting from immune injury","author":"Packman CH","year":"2006"},{"key":"e_1_2_1_15_2","first-page":"66","article-title":"Immunopathologic and clinical features of hemolytic anemia due to cold agglutinins","volume":"28","author":"Nydegger UE","year":"1991","journal-title":"Semin Hematol"},{"key":"e_1_2_1_16_2","first-page":"227","article-title":"Severe cold agglutinin disease and cryoglobulinemia secondary to a monoclonal anti\u2010Pr2 IgM lambda cryoagglutinin","volume":"17","author":"Ciejka JZ","year":"1999","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830190413"},{"key":"e_1_2_1_18_2","first-page":"460","article-title":"Primary chronic cold agglutinin disease: A population based clinical study of 86 patients","volume":"91","author":"Berentsen S","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1994.tb00197.x"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-111-3-255"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03078.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-10-3597"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1182\/blood.V92.9.3490","article-title":"Rituxan in the treatment of cold agglutinin disease","volume":"92","author":"Lee EJ","year":"1998","journal-title":"Blood"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197810)42:4<1826::AID-CNCR2820420422>3.0.CO;2-X"},{"key":"e_1_2_1_25_2","first-page":"174","article-title":"Cold agglutinin disease and cryoglobulinemia. Report of two cases","volume":"70","author":"Buonanno G","year":"1985","journal-title":"Haematologica"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.21330","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.21330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T03:21:04Z","timestamp":1699932064000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.21330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,18]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1002\/ajh.21330"],"URL":"https:\/\/doi.org\/10.1002\/ajh.21330","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,18]]}}}