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Forty\u2010five cases were selected in whom 38 cases were of diffuse large B\u2010cell lymphoma. A complete analysis was then performed on these 38 patients. Twenty out of 28 cases (71%) of cases were Bcl\u20102 positive and four out of 28 (14%) had a CD10 positive staining. Peculiar initial characteristics showed nodal involvement in 58% of the cases and two or more extra\u2010nodal sites in 31% of the cases. Among the 37 patients for whom all data were available, and according to the International Prognostic Index, 19 patients (51%) were classified in the low\u2010risk group, 5 cases (14%) in the low\u2010 to intermediate\u2010risk group, 6 patients (16%) in the intermediate\u2010 to high\u2010risk group, and 7 (19%) case in the high\u2010risk group. At the end of initial therapy, 34 patients (89%) achieved CR. With a median follow\u2010up of 96 months, 18 patients (47%) relapsed of whom 3 had a relapse in central nervous system site. The 5\u2010year disease\u2010free (DFS) and overall survivals (OS) were 54% and 61%, respectively. In multivariate analysis, the presence of 2 or more extranodal sites was prognostic for lower DFS (<jats:italic>P<\/jats:italic>= 0.0008) and OS (<jats:italic>P<\/jats:italic>= 0.09), and a performance status \u22651 was prognostic for lower OS (<jats:italic>P<\/jats:italic>= 0.005). Finally, when our series was compared with a historical series of 111 patients with aggressive nodal lymphomas, we observed significant lower survival rates in localized PBL (<jats:italic>P<\/jats:italic>&lt; 0.03). Initial breast localization has a pejorative impact on the outcome of patients with Non\u2010Hodgkin's Lymphoma (NHL), with an impressive adverse influence of additional extranodal sites. These results suggest a specific management of NHL with breast involvement. Am. J. Hematol., 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21353","type":"journal-article","created":{"date-parts":[[2008,12,17]],"date-time":"2008-12-17T06:12:44Z","timestamp":1229494364000},"page":"133-139","source":"Crossref","is-referenced-by-count":75,"title":["Primary breast non\u2010Hodgkin's lymphoma: A large single center study of initial characteristics, natural history, and prognostic factors"],"prefix":"10.1002","volume":"84","author":[{"given":"Patricia","family":"Validire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Capovilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Asselain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youlia","family":"Kirova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Goudefroye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corine","family":"Plancher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Fourquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Zanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gaulard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Vincent\u2010Salomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Decaudin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,6]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"613","article-title":"Generalized sarcomatosis (lymphosarcomatosis) in pregnancy with unusual bilateral involvement of the breasts","volume":"5","author":"Dobrotina AF","year":"1959","journal-title":"Vopr Onkol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199306000-00005"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-199808000-00012"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.5858\/1999-123-1208-LOTB"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10163"},{"key":"e_1_2_1_7_2","first-page":"441","article-title":"Frequency and characteristics of breast lymphomas presenting to a tertiary care hospital, Pakistan","volume":"56","author":"Yaqoob N","year":"2006","journal-title":"J Pak Med Assoc"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910301)67:5<1359::AID-CNCR2820670515>3.0.CO;2-4"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199403000-00009"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/1042819031000079195"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-200008000-00003"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800740322"},{"key":"e_1_2_1_13_2","first-page":"85","article-title":"Breast lymphoma. 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