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We report a retrospective analysis of the long\u2010term outcome of 386 consecutive ET patients, followed at single Institution for a median follow\u2010up of 9.5 years (range, 3\u201328.5). Cytoreductive therapy was administered to 338 patients (88%), obtaining a response in 86% of cases. Forty\u2010five patients (12%) experienced a thrombosis. Among baseline characteristics, only history of vascular events prior to ET diagnosis predicted a higher incidence of thrombosis. Evolution in acute leukemia\/myelofibrosis occurred in 6 (1,5%) and 20 (5%) patients, and was significantly higher in patients receiving sequential cytotoxic agents. Overall survival was 38% at 19 years and was poorer for patients older than 60 years, with higher leukocytes count (&gt;15 \u00d7 10<jats:sup>9<\/jats:sup>\/L), hypertension and mellitus diabetes at ET diagnosis and for patients experiencing a thrombotic event during follow\u2010up. Cytoreductive therapy was effective in decreasing platelet number with negligible toxicity; however, thrombocytosis control did not reduce the incidence of thrombosis and, for patients who received sequential therapies, the probability of disease evolution was higher and survival was poorer. Am. J. Hematol. 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21360","type":"journal-article","created":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T08:38:48Z","timestamp":1230885528000},"page":"215-220","source":"Crossref","is-referenced-by-count":65,"title":["Long\u2010term follow\u2010up of 386 consecutive patients with essential thrombocythemia: Safety of cytoreductive 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