{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:34:06Z","timestamp":1789932846249,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Baseline level of the cysteinyl leukotriene (CysLT), leukotriene E<jats:sub>4<\/jats:sub> (LTE<jats:sub>4<\/jats:sub>), is associated with an increased pain rate in children and adults with sickle cell disease (SCD). To provide additional evidence for a role of CysLTs in the pathogenesis of vaso\u2010occlusion, we tested the hypothesis that LTE<jats:sub>4<\/jats:sub> levels will increase within an individual during painful episodes compared to baseline. In a cohort of 19 children and adults with SCD, median LTE<jats:sub>4<\/jats:sub> levels increased from 82.36 pg\/mg creatinine at baseline to 162.81 pg\/mg creatinine during a painful episode (<jats:italic>P<\/jats:italic> &lt; 0.001). These data further support a contribution of CysLTs to the process of vaso\u2010occlusion. Am. J. Hematol., 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21370","type":"journal-article","created":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T18:58:42Z","timestamp":1233601122000},"page":"231-233","source":"Crossref","is-referenced-by-count":26,"title":["Urinary cysteinyl leukotriene E<sub>4<\/sub> significantly increases during pain in children and adults with sickle cell disease"],"prefix":"10.1002","volume":"84","author":[{"given":"Joshua J.","family":"Field","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Strunk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica E.","family":"Knight\u2010Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morey A.","family":"Blinder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Reid","family":"Townsend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"DeBaun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,3,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199107043250103"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071371"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.supplement_1.ltta-20"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840200406"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1989.tb00306.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.supplement_2.13tac180"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91073-U"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.11.3304"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.7.4354"},{"key":"e_1_2_1_11_2","first-page":"19","article-title":"The mechanism of vascular leakage induced by leukotriene E4. Endothelial contraction","volume":"126","author":"Joris I","year":"1987","journal-title":"Am J Pathol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.25"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1586\/17474086.2.1.57"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21199"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21348"},{"key":"e_1_2_1_16_2","first-page":"293","article-title":"The environment and disease: Association or causation?","volume":"58","author":"Hill A","year":"1965","journal-title":"Proc R Soc Med"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21275"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.21370","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.21370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T18:19:22Z","timestamp":1699985962000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.21370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,16]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1002\/ajh.21370"],"URL":"https:\/\/doi.org\/10.1002\/ajh.21370","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,16]]}}}