{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:08:15Z","timestamp":1764936495759},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,4,9]],"date-time":"2009-04-09T00:00:00Z","timestamp":1239235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent studies on normal and malignant B\u2010cells have provided evidence that the germinal center (GC) of lymphoid follicles exerts a role in B\u2010cell physiology and malignancy. GC\u2010derived lymphomas include both B\u2010cell and T\u2010cell lymphomas. Remarkably, tumor cells of GC\u2010derived lymphomas proliferate in close association with cellular environment that retains key features of normal GC cellular microenvironment. Neoplastic follicles in follicular lymphoma contain, in addition to follicular dendritic cells (FDC) other non\u2010neoplastic cells including macrophages and GC T\u2010cells. In addition to aggregates of FDCs, the background infiltrate of nodular lymphocyte predominant Hodgkin lymphoma includes small B\u2010cells, T\u2010cells, and histiocytes. Typically, most of the lymphocyte predominant (LP) cells are ringed by CD3+\/CD4+ T\u2010cells expressing CD57, PD1, BCL6, and MUM1\/IRF4. By contrast, Reed\u2013Sternberg cells of classic Hodgkin lymphoma (cHL) are surrounded by CD3+\/CD4+ T\u2010cells expressing CD40L. Unlike cHL and other peripheral T\u2010cell lymphomas, the AITL microenvironment characteristically contain a prominent proliferation of high endothelial venules and FDC. Thus, these findings shed new light on the characterization of GC\u2010derived lymphomas and may help in the differential diagnosis and acknowledge several novel pathogenetic mechanisms on these lymphomas. Am. J. Hematol., 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21434","type":"journal-article","created":{"date-parts":[[2009,4,9]],"date-time":"2009-04-09T17:12:34Z","timestamp":1239297154000},"page":"435-438","source":"Crossref","is-referenced-by-count":15,"title":["Differentiating germinal center\u2010derived lymphomas through their cellular microenvironment"],"prefix":"10.1002","volume":"84","author":[{"given":"Antonino","family":"Carbone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annunziata","family":"Gloghini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonello","family":"Cabras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliano","family":"Elia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,5,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90047-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(93)90065-O"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.001001"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2217"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.07.009"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2120"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05573"},{"key":"e_1_2_1_9_2","article-title":"The germinal centre\u2010derived lymphomas seen through their cellular microenvironment","author":"Carbone A","journal-title":"Br J Haematol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2007.02207.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008265532487"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-077982"},{"key":"e_1_2_1_13_2","first-page":"220","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Harris NL","year":"2008"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-579X(03)00015-4"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1988.tb06192.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)90619-1"},{"key":"e_1_2_1_17_2","first-page":"912","article-title":"CD40 ligand is constitutively expressed in a subset of T cell lymphomas and on the microenvironmental reactive T cells of follicular lymphomas and Hodgkin's disease","volume":"147","author":"Carbone A","year":"1995","journal-title":"Am J Pathol"},{"key":"e_1_2_1_18_2","first-page":"323","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Poppema S","year":"2008"},{"key":"e_1_2_1_19_2","first-page":"457","article-title":"Nodular lymphocyte predominance type of Hodgkin's disease is a germinal center lymphoma","volume":"54","author":"Timens W","year":"1986","journal-title":"Lab Invest"},{"key":"e_1_2_1_20_2","first-page":"351","article-title":"The nature of the lymphocytes surrounding Reed\u2010Sternberg cells in nodular lymphocyte predominance and in other types of Hodgkin's disease","volume":"135","author":"Poppema S","year":"1989","journal-title":"Am J Pathol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200008000-00004"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03456.x"},{"key":"e_1_2_1_23_2","first-page":"326","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Stein H","year":"2008"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/108.6.687"},{"key":"e_1_2_1_25_2","volume-title":"Epstein\u2010Barr virus","author":"Murray PG","year":"2005"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/mp.53.5.262"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.3.780.bloodjournal853780"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.6.2084"},{"issue":"1","key":"e_1_2_1_29_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/annonc\/11.suppl_1.S3","article-title":"Lymphoma classification\u2013from controversy to consensus: The R.E.A.L. and WHO classification of lymphoid neoplasms","volume":"11","author":"Harris NL","year":"2000","journal-title":"Ann Oncol"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a059281"},{"key":"e_1_2_1_31_2","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/oxfordjournals.annonc.a059273","article-title":"Angioimmunoblastic T\u2010cell lymphoma: New insights, but the clinical challenge remains","volume":"6","author":"Jaffe ES","year":"1995","journal-title":"Ann Oncol"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008200307625"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.2.627"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-1708"},{"key":"e_1_2_1_35_2","first-page":"309","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Dogan A","year":"2008"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200604000-00009"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-055145"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e328186ffbf"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1083"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-1206"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080809"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.21434","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.21434","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:45:15Z","timestamp":1700009115000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.21434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,29]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["10.1002\/ajh.21434"],"URL":"https:\/\/doi.org\/10.1002\/ajh.21434","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,29]]}}}