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At BP, 63% of patients had leukocytosis (white blood cell count &gt;10 \u00d7 10<jats:sup>9<\/jats:sup>\/L), 74% had anemia (hemoglobin value &lt;10 g\/dL), 74% had thrombocytopenia (platelet count &lt;100 \u00d7 10<jats:sup>9<\/jats:sup>\/L), and 84% were over 65 years of age. Cytogenetic analysis was available in 10 patients: six had karyotype aberrations. According to cytogenetic\u2010based risk stratification of de novo acute leukemia (AL), all patients had an unfavorable profile. <jats:italic>JAK2<\/jats:italic> (V617F) mutational status was evaluated in five patients. In two of them, the <jats:italic>JAK2<\/jats:italic> mutation was undetectable in blast cells (one with <jats:italic>JAK2<\/jats:italic>\u2010positive ET), whereas in three both granulocytes and blast cells displayed the mutation. Treatment of BP was patient\u2010based according to the performance status and co\u2010morbidities and consisted of palliation in 14 patients, and of induction of remission in five. Median survival was 2.3 months (range 0.2\u201322.3), irrespective of the treatment received. In conclusion, this study indicates that AL evolved from ET has unfavorable clinical and biological features. <jats:italic>JAK2<\/jats:italic> (V617F)\u2010positive ET may evolve in few instances into <jats:italic>JAK2<\/jats:italic>\u2010negative leukemia. The outcome of patients is poor whatever the treatment used. Am. J. Hematol., 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21496","type":"journal-article","created":{"date-parts":[[2009,7,17]],"date-time":"2009-07-17T16:43:31Z","timestamp":1247849011000},"page":"641-644","source":"Crossref","is-referenced-by-count":7,"title":["Blast phase of essential thrombocythemia: A single center 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