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All patients aged \u226518 years seen at the Adult Sickle Cell Center at Duke University Medical Center between January 2000 and April 2005 were enrolled. Forty\u2010three patients (21 males and 22 females) died during the study period. The median age of survival was 39 years for females (95% CI: 34\u201356), 40 years for males (95% CI: 34\u201348), and 40 years overall (95% CI: 35\u201348). Cardiac causes of death accounted for 25.6% (11\/43 patients); pulmonary, 14.0% (six patients); other SCD related, 32.6% (14 patients); unknown, 14.0% (six patients); and others, 14.0% (six patients). Pulseless electrical activity arrest, pulmonary emboli, multiorgan failure, and stroke were the most frequent causes of death. Among the deceased patients, the most common premorbid conditions were cardiopulmonary: acute chest syndrome\/pneumonia (58.1%), Pulmonary hypertension (pHTN; 41.9%), systemic HTN (25.6%), congestive heart failure (25.6%), myocardial infarction (20.9%), and arrhythmias (14.0%). Tricuspid regurgitant jet velocity was significantly higher (3.1 m\/sec vs. 2.6 m\/sec, <jats:italic>P<\/jats:italic> &lt; 0.001) and hemoglobin significantly lower (8.3 g\/dL vs. 9.2 g\/dL, <jats:italic>P<\/jats:italic> &lt; 0.05) in deceased patients when compared with patients who lived, respectively. With improved preventive and therapeutic advances, including hydroxyurea therapy, acute complications such as infection are no longer the leading cause of death; instead, causes of death and premorbid conditions are shifting to chronic cardiopulmonary complications. Further, arrhythmia leading to premature death is under\u2010recognized in SCD and warrants further investigation. Am. J. Hematol., 2010. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21569","type":"journal-article","created":{"date-parts":[[2009,10,16]],"date-time":"2009-10-16T17:21:56Z","timestamp":1255713716000},"page":"36-40","source":"Crossref","is-referenced-by-count":206,"title":["Cardiopulmonary complications leading to premature deaths in adult patients with sickle cell disease"],"prefix":"10.1002","volume":"85","author":[{"given":"Courtney D.","family":"Fitzhugh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naudia","family":"Lauder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jude C.","family":"Jonassaint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn 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