{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T04:45:03Z","timestamp":1746333903474},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,10,27]],"date-time":"2009-10-27T00:00:00Z","timestamp":1256601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Metabolic pathway enzymes, such as Cytochrome P450 (CYP), glutathione S\u2010transferase (GST), and <jats:italic>N<\/jats:italic>\u2010acetyltransferases (NAT) are involved in activation and detoxification of environmental carcinogens as well as drug metabolism. We hypothesized that the genetic variations in such metabolic pathways may affect NHL prognosis and survival. Follow\u2010up information of 496 female NHL incident cases diagnosed during 1996\u20132000 in Connecticut were abstracted from the Connecticut Tumor Registry in 2008; survival analyses were conducted by comparing the Kaplan\u2010Meier curves, and hazard ratios (HR) were computed from the Cox Proportional Hazard models adjusting for demographic and tumor characteristics which were suggested by previous studies to be determinants of NHL survival. We identified six SNPs from four metabolism genes (<jats:italic>CYP2E1, GSTP1, GSTT1,<\/jats:italic> and <jats:italic>NAT1<\/jats:italic>) that were associated with NHL survival. Specifically, polymorphisms in <jats:italic>GSTT1<\/jats:italic> were associated with follicular lymphoma survival; and polymorphisms in <jats:italic>CYP2E1, GSTP1,<\/jats:italic> and <jats:italic>NAT1<\/jats:italic> were associated with survival of chronic lymphocytic leukemia\/small lymphocytic lymphoma. Our study suggests that genetic polymorphisms in metabolic pathways may help improve the prediction of NHL survival and prognosis. Am. J. Hematol., 2010. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21580","type":"journal-article","created":{"date-parts":[[2009,10,27]],"date-time":"2009-10-27T20:43:30Z","timestamp":1256676210000},"page":"51-56","source":"Crossref","is-referenced-by-count":22,"title":["Genetic polymorphisms in the metabolic pathway and non\u2010Hodgkin lymphoma survival"],"prefix":"10.1002","volume":"85","author":[{"given":"Xuesong","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongzhang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francine M.","family":"Foss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore R.","family":"Holford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathaniel","family":"Rothman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuangge","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yawei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,12,22]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"SEER Cancer Statistics Review, 1975\u20132005","author":"Ries LAG"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2508"},{"key":"e_1_2_1_4_2","first-page":"235","volume-title":"Cancer Survival Among Adults: US SEER Program, 1988\u20132001, Patient and Tumor Characteristics","author":"Clarke C","year":"2007"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9147-4"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291402"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041869"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012914"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701704605"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21113"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0193"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.12.1265"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1007\/s00420-002-0353-1","article-title":"Genetic polymorphisms of biotransformation enzymes in patients with Hodgkin's and non\u2010Hodgkin's lymphomas","volume":"75","author":"Soucek P","year":"2002","journal-title":"Int Arch Occup Environ Health"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0343"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03606.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-12-3803"},{"key":"e_1_2_1_17_2","first-page":"1015","article-title":"Effect of interleukin\u20101beta and glutathione S\u2010transferase genotypes on the development of gastric mucosa\u2010associated lymphoid tissue lymphoma","volume":"89","author":"Wu MS","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05358.x"},{"key":"e_1_2_1_19_2","first-page":"709","article-title":"Polymorphisms within glutathione S\u2010transferase genes in pediatric non\u2010Hodgkin's lymphoma","volume":"87","author":"Dieckvoss BO","year":"2002","journal-title":"Haematologica"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.fpc.0000215071.59836.29"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025626208861"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh033"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1182\/blood.V89.11.3909","article-title":"The Non\u2010Hodgkin's Lymphoma Classification Project. 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