{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T13:46:14Z","timestamp":1764510374963},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T00:00:00Z","timestamp":1263945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The chemotherapy dose\u2010intensity in two adapted German BFM paediatric protocols (BFM 90 and NHL 86) was compared in contemporaneously treated adults &lt;50 years with Burkitt lymphoma and B\u2010cell lymphoma unclassifiable, with features intermediate between diffuse large B\u2010cell lymphoma and Burkitt lymphoma (collectively referred to as BL). In BFM 90, primary prophylaxis with Granulocyte\u2010colony\u2010stimulating factor was used, postinduction treatment was started at granulocytes \u22650.5 \u00d7 10<jats:sup>9<\/jats:sup>\/L (\u22651.0 \u00d7 10<jats:sup>9<\/jats:sup>\/L in NHL 86) with a higher mean methotrexate dose (2.9 g\/m<jats:sup>2<\/jats:sup>\/cycle, <jats:italic>n<\/jats:italic> = 23; 1.6 g\/m<jats:sup>2<\/jats:sup>\/cycle in NHL 86, <jats:italic>n<\/jats:italic> = 22, <jats:italic>P<\/jats:italic> &lt; 0.001). Intervals between consecutive treatment\u2010cycles were shorter in BFM 90 (<jats:italic>P<\/jats:italic> &lt; 0.001) with no additional toxicity. However, the two\u2010year failure\u2010free survival with BFM 90 (82%) was similar to that achieved with NHL 86 (72%, <jats:italic>P<\/jats:italic> = 0.33). We conclude that BFM 90 enables safe intensification of therapy in young adults with BL compared to NHL 86, but registry\u2010based studies are required to further evaluate the antineoplastic effects and cost\u2010effectiveness of the two therapeutic approaches. Am. J. Hematol., 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21648","type":"journal-article","created":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T15:43:12Z","timestamp":1264002192000},"page":"261-263","source":"Crossref","is-referenced-by-count":7,"title":["Dose\u2010intensified treatment of Burkitt lymphoma and B\u2010cell lymphoma unclassifiable, (with features intermediate between diffuse large B\u2010cell lymphoma and Burkitt lymphoma) in young adults (&lt;50 years): A comparison of two adapted BFM protocols"],"prefix":"10.1002","volume":"85","author":[{"given":"Sudhir","family":"Tauro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynda","family":"Cochrane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grete Fossum","family":"Lauritzsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Delabie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Premini","family":"Mahendra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Holte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,3,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0405"},{"key":"e_1_2_1_3_2","first-page":"3294","article-title":"Improved treatment results in childhood B\u2010cell neoplasms with tailored intensification of therapy: A report of the Berlin\u2010Frankfurt\u2010M\u00fcnster Group Trial NHL\u2010BFM90","volume":"49","author":"Reiter A","year":"1999","journal-title":"Blood"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-0973"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.2002.00429.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh262"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1182\/blood.V80.10.2471.2471","article-title":"Favourable outcome of B\u2010cell acute lymphoblastic leukaemia in childhood: A report of three consecutive studies of the BFM group","volume":"80","author":"Reiter A","year":"1992","journal-title":"Blood"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.2.359"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-145128"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03620.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06598.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"8035","DOI":"10.1200\/jco.2007.25.18_suppl.8035","article-title":"Efficacy and toxicity of dose\u2010adjusted EPOCH\u2010rituximab in adults with newly diagnosed Burkitt lymphoma","volume":"18","author":"Dunleavy K","year":"2007","journal-title":"J Clin Oncol"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.21648","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.21648","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T03:37:37Z","timestamp":1700624257000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.21648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,3]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["10.1002\/ajh.21648"],"URL":"https:\/\/doi.org\/10.1002\/ajh.21648","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,3]]}}}