{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:02:41Z","timestamp":1780480961525,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,5,23]],"date-time":"2010-05-23T00:00:00Z","timestamp":1274572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is a causal association between <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>Hp<\/jats:italic>) gastric infection and the development of gastric MALT lymphoma. In contrast, the link between <jats:italic>Hp<\/jats:italic> gastric infection and the development of extragastric lymphoma has not been thoroughly investigated. We, therefore, studied the prevalence of gastric <jats:italic>Hp<\/jats:italic> infection at initial diagnosis of ophthalmologic and nonophthalmologic extragastric lymphoma patients. Three cohorts of patients were studied: a first one of 83 patients with OAL, a second one of 101 patients with extraophthalmologic extragastric lymphoma, and a third one of 156 control individuals (control) without malignant lymphoma. Gastric <jats:italic>Hp<\/jats:italic> infection was investigated by histopathological analysis and <jats:italic>Hp<\/jats:italic>\u2010specific PCR assay on gastric biopsy tissue samples. We found gastric <jats:italic>Hp<\/jats:italic> infection in 37 OAL patients (45%), in 25 extraophthalmologic extragastric lymphoma cases (25%), and in 18 controls individuals (12%) (<jats:italic>P<\/jats:italic> &lt; 0.0001 OAL\/C and <jats:italic>P<\/jats:italic> &lt; 0.01 OAL\/extra\u2010OAL cases). Gastritis was found in 51% and 9% of <jats:italic>Hp<\/jats:italic>\u2010positive and <jats:italic>Hp<\/jats:italic>\u2010negative lymphoma patients, respectively (<jats:italic>P<\/jats:italic> &lt; 10<jats:sup>\u22124<\/jats:sup>). Gastric <jats:italic>Hp<\/jats:italic> infection only correlated with MALT\/LPL lymphoma (<jats:italic>P<\/jats:italic> = 0.03). There is a significant association between gastric <jats:italic>Hp<\/jats:italic> infection and MALT\/LPL OAL. This suggests a novel mechanism of indirect infection\u2010associated lymphomagenesis whereby chronic local antigen stimulation would lead to the emergence of ectopic B\u2010cell lymphoma. \u00a9 2010 Wiley\u2010Liss, Inc. 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