{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:25:16Z","timestamp":1791033916275,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T00:00:00Z","timestamp":1276560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The reproducibility of tricuspid regurgitant jet velocity (TRJV) measurements by Doppler echocardiography has not been subjected to systematic evaluation among individuals with sickle cell disease (SCD) undergoing screening for pulmonary hypertension. We examined sources of disagreement associated with peak TRJV in children and young adults with SCD. Peak TRJV was independently measured and interpreted a week apart by separate sonographers and readers, respectively, in 30 subjects (mean age, 15.8 \u00b1 3.3 years) who provided 120 observations. We assessed intra\u2010\/inter\u2010reader, intra\u2010\/inter\u2010sonographer, sonographer\u2010reader, and within subject agreement using Intraclass Correlation Coefficient (ICC) and Cohen's kappa (\u03ba). Agreement was examined graphically using Bland\u2010Altman plots. Although sonographers could estimate and measure peak TRJV in all subjects, readers designated tricuspid regurgitation nonquantifiable in 10\u201317% of their final interpretations. Intra\u2010reader agreement was highest (ICC = 0.93 [95% CI 0.86, 0.97], <jats:italic>P<\/jats:italic> = 0.0001) and within subject agreement lowest (ICC = 0.36 [95% CI 0.02, 0.64], <jats:italic>P<\/jats:italic> = 0.021) for single TRJV measurements. Similarly, intra\u2010reader agreement was highest (\u03ba = 0.74 [95% CI 0.53, 0.95], <jats:italic>P<\/jats:italic> = 0.0001) and within subject lowest (\u03ba = 0.14 [95% CI \u22120.17, 0.46], <jats:italic>P<\/jats:italic> = 0.38) when sonographers and readers categorized TRJV measurements. On Bland\u2010Altman plots, absolute differences in observations increased with higher mean TRJV readings for intra\u2010\/inter\u2010reader agreement. Peak TRJV measurements in individual children and young adults with SCD are affected by several sources of disagreement, underscoring the need for methodological improvements that ensure reproducibility of this screening modality for making clinical decisions in this population. Am. J. Hematol., 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21793","type":"journal-article","created":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T16:05:05Z","timestamp":1276617905000},"page":"741-745","source":"Crossref","is-referenced-by-count":19,"title":["Reproducibility of tricuspid regurgitant jet velocity measurements in children and young adults with sickle cell disease undergoing screening for pulmonary hypertension"],"prefix":"10.1002","volume":"85","author":[{"given":"Robert I.","family":"Liem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana T.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy S.","family":"Lay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Pelligra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Labotka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis A.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06110.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21058"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035477"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20996"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-007-9018-x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0730"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192230"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.5.1836"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.4065\/81.6.777"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21433"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.126350"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80477-0"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.70.4.657"},{"key":"e_1_2_6_15_2","first-page":"157","article-title":"Role of 2\u2010dimensional Doppler echo\u2010cardiography in screening portopulmonary hypertension in portal hypertension patients","volume":"8","author":"Hua R","year":"2009","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2488"},{"key":"e_1_2_6_17_2","first-page":"458","article-title":"Assessment of pulmonary arterial hypertension in patients with systemic sclerosis: Comparison of noninvasive tests with results of right\u2010heart catheterization","volume":"35","author":"Hsu VM","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.116.1.73"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002469900080"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a059855"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euje.2005.06.003"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.123139"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07779.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07501.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V114.22.572.572"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.21793","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.21793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T02:04:04Z","timestamp":1700618644000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.21793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,15]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1002\/ajh.21793"],"URL":"https:\/\/doi.org\/10.1002\/ajh.21793","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,15]]}}}