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To comprehensively investigate the subtype distribution with the age and sex factors, and temporal changes of subtype proportions, we re\u2010assessed all patients with lymphoid neoplasms diagnosed at a large oncology service in the Republic of Korea from 1989 to 2008 using the World Health Organization classifications. Of the total 5,318 patients, 66.9% had mature B\u2010cell neoplasms, 12.5% had mature T\/natural killer (NK)\u2010cell neoplasms, 16.4% had precursor lymphoblastic leukemia\/lymphoma (ALL\/LBL), and 4.1% had Hodgkin's lymphoma. The most common subtypes were diffuse large B\u2010cell lymphoma (30.5%), plasma cell myeloma (14.0%), extranodal marginal zone lymphoma of mucosa\u2010associated lymphoid tissue type (MALT lymphoma; 12.4%), B\u2010cell ALL\/LBL (11.3%), Hodgkin's lymphoma (4.1%), peripheral T\u2010cell lymphoma unspecified (4.0%), T\u2010cell ALL\/LBL (3.9%), and extranodal NK\/T\u2010cell lymphoma of nasal type (3.9%). Most subtypes showed male predominance, with an average M\/F ratio of 1.3. Most mature lymphoid neoplasms were diseases of adults (mean age, 53.5 yr), whereas ALL\/LBLs were of young individuals (mean age, 20.3 yr). When the relative proportion of subtypes were compared between two decades (1989\u20131998 vs. 1999\u20132008), especially MALT lymphoma has increased in proportion, whereas T\/NK\u2010cell neoplasms and ALL\/LBL have slightly decreased. In summary, the lymphoid neoplasms of Koreans shared some epidemiologic features similar to those of other countries, whereas some subtypes showed distinct features. Although the increase in incidence of lymphoid neoplasms is relatively modest in Korea, recent increase of MALT lymphoma and decrease of T\/NK\u2010cell neoplasms and ALL\/LBL are interesting findings. Am. J. Hematol., 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21824","type":"journal-article","created":{"date-parts":[[2010,7,13]],"date-time":"2010-07-13T19:34:29Z","timestamp":1279049669000},"page":"760-764","source":"Crossref","is-referenced-by-count":112,"title":["Distribution of lymphoid neoplasms in the Republic of Korea: Analysis of 5318 cases according to the World Health Organization classification"],"prefix":"10.1002","volume":"85","author":[{"given":"Sun Och","family":"Yoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheolwon","family":"Suh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Sook","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Jeoung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong\u2010Soo","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Rim","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bong\u2010Hee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jooryung","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,7,13]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"Jaffe ES","year":"2001"},{"key":"e_1_2_6_3_2","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2007"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/11.suppl_1.S3"},{"key":"e_1_2_6_5_2","series-title":"International Association of Cancer Registries. 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