{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:03:57Z","timestamp":1762898637758},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,10,27]],"date-time":"2010-10-27T00:00:00Z","timestamp":1288137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We quantified and differentiated reticulin and collagen content in bone marrow specimens from chronic immune thrombocytopenic (ITP) patients and examined the correlation between some clinical characteristics and the fibrosis grading. Through the Danish National Patient Registry, we identified 378 patients with chronic ITP from 1997 until 2007. Of these, 253 (67%) had undergone at least one bone marrow biopsy, and we retrieved the bone marrow specimens from 187 (74%). We graded the bone marrow content of reticulin and collagen according to the Thiele scale (Grade 0\u20133). We also retrieved information on patients' clinical characteristics. We examined the prevalence of bone marrow fibrosis grading &gt;0 by patients' age (\u226475 years and &gt;75 years), sex, platelet count at baseline (&lt;30 \u00d7 10<jats:sup>9<\/jats:sup>\/L, and \u226530 \u00d7 10<jats:sup>9<\/jats:sup>\/L), splenomegaly, hepatomegaly, and medications. In total 75 chronic ITP patients (40%) had a bone marrow grading &gt;0. Of these, 72 (39%) had Grade 1 reticulin fibers present. Only three patients (&lt;2%) had collagen fibers present: two had Grade 2 and one had Grade 3. The prevalence of bone marrow grading &gt;0 was lower in patients aged &gt;75 years than \u226475 years (prevalence ratio = 0.64, 95% CI: 0.36\u20131.15) and lower in men than women (prevalence ratio = 0.70, 95% CI: 0.45\u20131.09), while a baseline platelet count \u226530 \u00d7 10<jats:sup>9<\/jats:sup>\/L was associated with a higher prevalence of grading &gt;0 (prevalence ratio = 1.24, 95% CI: 0.81\u20131.86). Thus, bone marrow reticulin and collagen content in chronic ITP patients may be associated with some clinical characteristics. Am. J. Hematol., 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21885","type":"journal-article","created":{"date-parts":[[2010,9,17]],"date-time":"2010-09-17T19:29:35Z","timestamp":1284751775000},"page":"930-934","source":"Crossref","is-referenced-by-count":13,"title":["Bone marrow reticulin and collagen content in patients with adult chronic immune thrombocytopenic purpura: A Danish nationwide study"],"prefix":"10.1002","volume":"85","author":[{"given":"Marianne Schmidt","family":"Ettrup","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette \u00d8stergaard","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malene Cramer","family":"Engebjerg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00f3ra K\u00f6rmendin\u00e9","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette","family":"N\u00f8rgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Cha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preben","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik Toft","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,10,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-162503"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2007.00998.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2007.11.002"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2007.05.007"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.4.1342"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/56.1.24"},{"key":"e_1_2_6_8_2","unstructured":"MuftiG BaggA HasserjianRP et al.Bone marrow reticulin in patients with immune thrombocytopenic purpura. 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