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We also examined Bcr\u2010Abl expression at low and high levels as elevated expression has been associated with treatment failure. Cells expressing low levels of Bcr\u2010Abl undergo apoptosis in response to the DNA\u2010targeting agent (etoposide), whereas high\u2010Bcr\u2010Abl\u2010expressing cells primarily induce autophagy. Autophagic populations engage a delayed nonapoptotic death; however, sufficient cells evade this and repopulate following the withdrawal of the drug. Non\u2010Bcr\u2010Abl\u2010expressing 32D or Ba\/F3 cells induce both apoptosis and autophagy in response to etoposide and can recover. Imatinib treatment induces both apoptosis and autophagy in all Bcr\u2010Abl\u2010expressing cells and populations rapidly recover. Inhibition of autophagy with ATG7 and Beclin1 siRNA significantly reduced the recovery of Imatinib\u2010treated K562 cells, indicating the importance of autophagy for the recovery of treated cells. Combination regimes incorporating agents that disrupt Imatinib\u2010induced autophagy would remain primarily targeted and may improve response to the treatment in CML. Am. J. Hematol., 2011. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.21914","type":"journal-article","created":{"date-parts":[[2010,10,27]],"date-time":"2010-10-27T18:18:01Z","timestamp":1288203481000},"page":"38-47","source":"Crossref","is-referenced-by-count":42,"title":["Autophagy induction by Bcr\u2010Abl\u2010expressing cells facilitates their recovery from a targeted or nontargeted treatment"],"prefix":"10.1002","volume":"86","author":[{"given":"Lisa C.","family":"Crowley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baukje M.","family":"Elzinga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald C.","family":"O'Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon 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