{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:48:33Z","timestamp":1790880513515,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,2,15]],"date-time":"2011-02-15T00:00:00Z","timestamp":1297728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Current response criteria for light\u2010chain amyloidosis (AL) relegate FLC response to a subsidiary status relative to serum M\u2010protein response. Given that light chains form the substrate for amyloid fibril formation, we hypothesized that changes in FLC might better predict outcome compared to changes in intact immunoglobulin levels. Two patient cohorts were studied, 347 patients who underwent an autologous stem\u2010cell transplant (SCT) and 96 patients treated with melphalan\/dexamethasone. We identified the lowest value following therapy for intact serum M\u2010protein and the difference between involved and uninvolved FLC (FLC\u2010diff). We first examined the relative contribution of M\u2010protein and FLC\u2010diff on the overall survival (OS), and found that FLC reduction, rather than M\u2010protein reduction, significantly impacted OS. The median OS was not reached among those with a 50% decrease in FLC\u2010diff compared to 20 months for the remainder. On regression analysis, a 90% reduction in FLC\u2010diff following SCT best predicted being alive at 3 or 5 years. The median OS among those with a 90% decrease was not reached compared to 37.4 months for the rest\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001. The current study supports the notion that FLC response is a more useful measure of hematological response than M\u2010protein response. It also highlights the importance of achieving at least a 90% reduction in the FLC\u2010diff to improve the outcome of patients with light\u2010chain AL. Am. J. Hematol. 2011. \u00a9 2011 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ajh.21948","type":"journal-article","created":{"date-parts":[[2010,12,2]],"date-time":"2010-12-02T10:14:22Z","timestamp":1291284862000},"page":"251-255","source":"Crossref","is-referenced-by-count":80,"title":["Changes in serum\u2010free light chain rather than intact monoclonal immunoglobulin levels predicts outcome following therapy in primary amyloidosis"],"prefix":"10.1002","volume":"86","author":[{"given":"Shaji K.","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Dispenzieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha Q.","family":"Lacy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne R.","family":"Hayman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis K.","family":"Buadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Zeldenrust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tow","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirshendu","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Kyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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