{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:37:35Z","timestamp":1787060255155,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,4,26]],"date-time":"2011-04-26T00:00:00Z","timestamp":1303776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    World Health Organization (WHO) criteria were used to identify 143 consecutive patients (median age 73 years; 90 females) with myeloid neoplasms and isolated del(5q) seen between 1989 and 2009. We have previously reported on 88 (61%) of these patients who met criteria for WHO defined \u201cmyelodysplastic syndromes (MDS) with isolated del(5q).\u201d The remaining 55 patients were classified as having \u201cother\u201d MDS variants (\n                    <jats:italic>n<\/jats:italic>\n                    = 29; 20%), acute myeloid leukemia (AML;\n                    <jats:italic>n<\/jats:italic>\n                    = 14; 10%), or myeloproliferative neoplasms (MPN;\n                    <jats:italic>n<\/jats:italic>\n                    = 12; 8%). DNA was available in 138 patients and mutation screening revealed 20 cases with\n                    <jats:italic>JAK2<\/jats:italic>\n                    , 6 with\n                    <jats:italic>IDH<\/jats:italic>\n                    , and 3 with\n                    <jats:italic>MPL<\/jats:italic>\n                    mutations;\n                    <jats:italic>JAK2<\/jats:italic>\n                    and\n                    <jats:italic>MPL<\/jats:italic>\n                    mutations were seen mostly in MPN or \u201cMDS with isolated del(5q)\u201d whereas\n                    <jats:italic>IDH<\/jats:italic>\n                    mutations were frequent in other MDS variants. Overall median survival for the 143 patient cohort was 35 months and leukemic transformation (LT) was documented in 19 (\u223c13%) cases. \u201cMDS with isolated del(5q)\u201d had the best prognosis with median survival of 66 months and LT rate of \u223c6%. Survival was poor among the other myeloid neoplasm subgroups regardless of specific morphologic diagnosis. Multivariable analysis identified higher leukocyte count and percentage of bone marrow and circulating blasts as independent predictors of shortened survival. The first two parameters and the presence of\n                    <jats:italic>IDH<\/jats:italic>\n                    mutations predicted inferior leukemia\u2010free survival. The current study validates the prognostic relevance of considering \u201cMDS with isolated del(5q)\u201d as a separate WHO subcategory and identifies leukocytosis, higher blast count, and\n                    <jats:italic>IDH<\/jats:italic>\n                    mutations as being prognostically detrimental, in myeloid neoplasms associated with isolated del(5q). Am. J. Hematol. 86:393\u2013398, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ajh.21984","type":"journal-article","created":{"date-parts":[[2011,1,27]],"date-time":"2011-01-27T11:26:23Z","timestamp":1296127583000},"page":"393-398","source":"Crossref","is-referenced-by-count":20,"title":["Isolated del(5q) in myeloid malignancies: Clinicopathologic and molecular features in 143 consecutive patients"],"prefix":"10.1002","volume":"86","author":[{"given":"Mrinal M.","family":"Patnaik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terra L.","family":"Lasho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy M.","family":"Finke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan A.","family":"Knudson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhett P.","family":"Ketterling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Hoyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis A.","family":"Hanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayalew","family":"Tefferi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,26]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.105"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2007.07.007"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-009-0846-z"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24575"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403189"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061292"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041668"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06494"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-01-068809"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404852"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1512"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06833.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.12.4638"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.231"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.98"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21245"},{"key":"e_1_2_5_18_2","first-page":"102","volume-title":"WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_5_19_2","volume-title":"An International System for Human Cytogenetic Nomenclature. 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