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We examined a series of 24 consecutive CML patients treated with nilotinib in our center for the development of non\u2010hematologic adverse events. Three of these 24 CML patients developed a rapidly progressive peripheral arterial occlusive disease (PAOD) during treatment with nilotinib. In all three cases, PAOD required repeated angioplasty and\/or multiple surgeries within a few months. No PAOD was known before nilotinib\u2010therapy in these patients, although all three had received imatinib. In two patients, pre\u2010existing risk factors predisposing for PAOD were known, and one of them had developed diabetes mellitus during nilotinib. In the other 21 patients treated with nilotinib in our center, one less severe PAOD, one myocardial infarction, one spinal infarction, one subdural hematoma, and one sudden death of unknown etiology were recorded. In summary, treatment with nilotinib may be associated with an increased risk of vascular adverse events, including PAOD development. In a subgroup of patients, these events are severe or even life\u2010threatening. Although the exact mechanisms remain unknown, we recommend screening for pre\u2010existing PAOD and for vascular risk factors such as diabetes mellitus in all patients before starting nilotinib and in the follow up during nilotinib\u2010therapy. Am. J. Hematol. 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajh.22037","type":"journal-article","created":{"date-parts":[[2011,3,25]],"date-time":"2011-03-25T14:59:39Z","timestamp":1301065179000},"page":"533-539","source":"Crossref","is-referenced-by-count":256,"title":["Progressive peripheral arterial occlusive disease and other vascular events during nilotinib therapy in CML"],"prefix":"10.1002","volume":"86","author":[{"given":"Karl 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