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For patients with disease limited to the skin, expectant management or skin\u2010directed therapies is preferred, as both disease\u2010specific and overall survival for these patients is favorable. In contrast, patients with advanced\u2010stage disease with significant nodal, visceral, or blood involvement are generally approached with biologic\u2010response modifiers, denileukin diftitox, and histone deacetylase inhibitors before escalating therapy to include systemic, single\u2010agent chemotherapy. Multiagent chemotherapy may be used for those patients with extensive visceral involvement requiring rapid disease control. In highly\u2010selected patients with disease refractory to standard treatments, allogeneic stem\u2010cell transplantation may be considered. Am. J. 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