{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:25:11Z","timestamp":1786976711003,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T00:00:00Z","timestamp":1321401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The optimal treatment of advanced sporadic Burkitt lymphoma in adults is still a matter of debate. The salutary results of pediatric therapies did open the road for improving the adult outcome. Between May 1988 and March 2009, 71 consecutive patients\u201446 adults, 25 children\u2014affected by Burkitt lymphoma\/leukemia were treated with the same intensive pediatric protocol alternating vincristine, adriamycine and fractionated ciclophosphamide (phase A) with high dose methotrexate and high dose cytarabine (phase B) in four Italian institutions. Eighty\u2010nine per cent of patients were in Stage III\u2013IV or had L3 leukemia. Complete remissions were 67\/71 (94.4%), 24\/25 (96%) in children, and 43\/46 (93.5%) in adults. Toxic deaths were 3\/71 (4.2%), all in adults. There were nine relapses (one in children, eight in adults), all but one observed early. After a median observation of 94 months (range 23\u2013275), the Event\u2013Free Survival rate is 92% in children and 71.7% in adults (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.067). The 23 more recent adults received also rituximab, without differences in outcome as compared to patients who did not. Our experience confirms that such an intensive pediatric\u2010derived chemotherapy is feasible and improves the long\u2010term outcome of adults with advanced Burkitt lymphoma. Am. J. Hematol., 2012. \u00a9 2011 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ajh.22189","type":"journal-article","created":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T21:38:26Z","timestamp":1315949906000},"page":"22-25","source":"Crossref","is-referenced-by-count":28,"title":["Intensive short\u2010term chemotherapy regimen induces high remission rate (over 90%) and event\u2010free survival both in children and adult patients with advanced sporadic Burkitt lymphoma\/leukemia"],"prefix":"10.1002","volume":"87","author":[{"given":"Giuseppe","family":"Todeschini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Bonifacio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Tecchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Balter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Carli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero 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