{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:51:14Z","timestamp":1791078674696,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,11,4]],"date-time":"2011-11-04T00:00:00Z","timestamp":1320364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Changes in several components of the clotting system are well documented in sickle cell disease (SCD) patients. However, whether the global hemostatic potential of these patients is altered is still unclear. Calibrated automated thrombogram\u00ae method of thrombin generation (TG) was used to characterize the hemostatic potential of 83 SCD children (75 SS, 6 SC, and 2 S\u03b2\n                    <jats:sup>thal<\/jats:sup>\n                    ) at steady\u2010state as compared with 50 controls of the same range of age. TG was triggered using 1 pM tissue factor and 4 \u03bcM phospholipids with and without thrombomodulin. Thirteen SCD children were also evaluated during vaso\u2010occlusive crisis. Protein C activity, free protein S and D\u2010dimers levels were measured in parallel. SCD patients showed higher rates of thrombin formation, higher thrombin peak height (with and without thrombomodulin), and higher endogenous thrombin potential (ETP) than controls in the presence of thrombomodulin. Reduction of ETP (RETP) in the presence of thrombomodulin was lower in SCD group compared with controls and correlated both with protein C and protein S levels. ETP, RETP, peak height, and velocity index of TG correlated with D\u2010dimers. Compound heterozygous patients showed an intermediate hemostatic phenotype at steady\u2010state. No significant difference was observed when comparing TG parameters during vaso\u2010occlusive crisis to those obtained at steady\u2010state in the same patients. The global hemostatic potential is increased and reflects the hypercoagulable state of SCD patients even at steady\u2010state. The relevance of this finding with respect to the risk of thrombotic complications of the disease needs further investigation. Am. J. Hematol. 2011. \u00a9 2011 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ajh.22206","type":"journal-article","created":{"date-parts":[[2011,9,30]],"date-time":"2011-09-30T16:47:47Z","timestamp":1317401267000},"page":"145-149","source":"Crossref","is-referenced-by-count":41,"title":["Thrombin generation reveals high procoagulant potential in the plasma of sickle cell disease children"],"prefix":"10.1002","volume":"87","author":[{"given":"Denis F.","family":"Noubouossie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phu 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