{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:23:23Z","timestamp":1761895403072},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T00:00:00Z","timestamp":1326067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A total of 149 patients with multiple myeloma (MM) who received allogeneic hematopoietic stem cell transplantation (allo\u2010HCT) with myeloablative (MAC; <jats:italic>n<\/jats:italic> = 38) or reduced\u2010intensity conditioning (RIC; <jats:italic>n<\/jats:italic> = 110) regimens at MD Anderson Cancer Center were evaluated. Of the total, 120 (81%) patients had relapsed or had refractory disease. Median age of MM patients was 50 (28\u201370) years with a followup time of 28.5 (3\u2013164) months. The 100\u2010day and 5\u2010year treatment related mortality (TRM) rates were 17% and 47%, respectively. TRM was significantly lower with RIC regimens (13%) vs. 29% for MAC at 100 days (<jats:italic>P<\/jats:italic> = 0.012). The cumulative incidence of Grade II\u2013IV acute graft\u2010versus\u2010host disease (GVHD) was 35% and chronic GVHD was 46%. PFS and OS at 5 years were 15% and 21%, respectively. In multivariate analysis, allo\u2010HCT for primary remission consolidation was associated with longer PFS (HR 0.35; 95% CI, 0.18\u20130.67) and OS (HR 0.29; 95% CI 0.15\u20130.55), while absence of high\u2010risk cytogenetics was associated with longer PFS only (HR 0.59; 95% CI 0.37\u20130.95). We observe that TRM has decreased with the use of RIC regimens, and long\u2010term disease control can be expected in a subset of MM patients undergoing allo\u2010HCT. Further studies should be conducted in carefully designed clinical trials in this patient population. Am. J. Hematol., 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.22273","type":"journal-article","created":{"date-parts":[[2011,12,17]],"date-time":"2011-12-17T06:39:22Z","timestamp":1324103962000},"page":"272-276","source":"Crossref","is-referenced-by-count":24,"title":["Predictors of prolonged survival after allogeneic hematopoietic stem cell transplantation for multiple myeloma"],"prefix":"10.1002","volume":"87","author":[{"given":"Qaiser","family":"Bashir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert Z.","family":"Orlowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali 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