{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:10:52Z","timestamp":1787314252455,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T00:00:00Z","timestamp":1334016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Lymphopenia is a marker of inferior survival in patients with various malignancies. However, the prognostic significance of lymphopenia in peripheral T\u2010cell lymphoma (PTCL) is unclear. We analyzed the prognostic significance of lymphopenia in 826 patients with different types of PTCL and natural killer\/T\u2010cell lymphoma (NKTCL) from the International Peripheral T\u2010cell Lymphoma Project. Lymphopenia was defined as an absolute lymphocyte count of less than 1,000 cells per microliter. The overall frequency of lymphopenia was 35.3%, ranging from 21.1% in ALK\n                    <jats:sup>+<\/jats:sup>\n                    anaplastic large cell lymphoma (ALCL) to 47.5% in angioimmunoblastic T\u2010cell lymphoma (AITL). Lymphopenia was independently associated with an inferior overall survival (OS) in patients with the lymphoma type of adult T\u2010cell leukemia\/lymphoma (ATLL), with a 2\u2010year OS of 15% versus 40% for those without lymphopenia (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001). Lymphopenia was also an adverse predictor of survival in PTCL, not otherwise specified, but was associated with other unfavorable prognostic factors. A trend toward inferior survival for lymphopenic patients was also observed in AITL, ALK\n                    <jats:sup>\u2212<\/jats:sup>\n                    ALCL and extranasal NKTCL lymphoma, whereas no difference in survival was found in nasal NKTCL, ALK\n                    <jats:sup>+<\/jats:sup>\n                    ALCL, or enteropathy\u2010associated T\u2010cell lymphoma. In this study, lymphopenia was identified as a new adverse prognostic factor in the lymphoma type of ATLL. Am. J. Hematol. 2012. \u00a9 2012 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ajh.23205","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T10:02:41Z","timestamp":1332237761000},"page":"790-794","source":"Crossref","is-referenced-by-count":43,"title":["The prognostic significance of lymphopenia in peripheral T\u2010cell and natural killer\/T\u2010cell lymphomas: A study of 826 cases from the International Peripheral T\u2010cell Lymphoma Project"],"prefix":"10.1002","volume":"87","author":[{"given":"Zdravko","family":"Mitrovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamarija M.","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Suzumiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James 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