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Platelets, for example, are known to access the vessel wall in ways which depend upon the small\u2010scale motions of neighboring erythrocytes, and access one another via collisions driven by gradients in blood flow velocity. In this context, flow devices have become a subject of great interest in the clinical assessment of bleeding disorders, especially platelet function defects and von Willebrand disease. While these devices currently lack standardization and outcomes measures which establish clear clinical utility, their promise remains great, particularly in the potential to simulate the microenvironment of arteries vs. veins and in their ability to incorporate such intrinsically flow\u2010dependent phenomena as co\u2010localization of tissue\u2010factor\u2010bearing microparticles with platelets, the weakness of the GPIb\u2010vWF bond at very high shear stresses, and even the hemostatic and antithrombotic function of vascular endothelium. In contrast, currently utilized assays are often performed under static conditions that do not involve flow and therefore are not able to simulate the microenvironment of arteries and veins. Am. J. Hematol., 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23207","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T14:02:44Z","timestamp":1332252164000},"source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of hemostasis in flowing blood"],"prefix":"10.1002","volume":"87","author":[{"given":"Eric F.","family":"Grabowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylee","family":"Yam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Gerace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,12]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Transport Phenomena and Living Systems","author":"Lightfoot EN","year":"1974"},{"key":"e_1_2_6_3_2","first-page":"43","article-title":"Inconsequentiality of initial platelet adhesion","volume":"16","author":"Friedman LI","year":"1970","journal-title":"Trans Amer Soc Artif Int Organs"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/i160042a012"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/i160042a013"},{"key":"e_1_2_6_6_2","first-page":"201","article-title":"Les lois de la transmission de chaleur par convection","volume":"13","author":"Leveque J","year":"1928","journal-title":"Annls Mines"},{"key":"e_1_2_6_7_2","volume-title":"Physicochemical Hydrodynamics","author":"Levich VG","year":"1962"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-2862(79)80002-3"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-2862(73)90069-1"},{"key":"e_1_2_6_10_2","first-page":"750","article-title":"Effect of shear rate on platelet interaction with subendothelium in citrated and native blood. 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