{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:35:05Z","timestamp":1782826505624,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,5,28]],"date-time":"2012-05-28T00:00:00Z","timestamp":1338163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prior studies describe an increased incidence of lymphoma in celiac disease. However, few studies differentiate among lymphoproliferative disorders (LPDs). Our aim was to determine incidences of LPD subtypes in celiac disease patients, describe patterns of celiac disease presentation in patients who develop LPD, and compare survival in patients with various LPD subtypes. We conducted a retrospective cohort study of adults with biopsy\u2010proven celiac disease seen at a US referral center from 1981 to 2010, identified patients with comorbid LPD, and calculated standardized incidence ratios (SIR) for each LPD subtype. In our cohort of 1,285 patients with celiac disease, there were 40 patients with LPD [SIR = 6.48, 95% confidence interval (CI) = 4.62\u20138.64] including 33 with non\u2010Hodgkin lymphoma (NHL, SIR = 6.91, 95% CI = 4.26\u20138.28). The incidences of NHL subtypes including enteropathy\u2010associated T\u2010cell (EATL, <jats:italic>n<\/jats:italic> = 12), non\u2010EATL T\u2010cell (SIR = 22.43, 95% CI = 7.08\u201346.41), diffuse large B\u2010cell (SIR = 5.37, 95% CI = 1.93\u201310.52), mantle cell (SIR = 32.21, 95% CI = 6.07\u201378.97), and marginal zone (SIR = 37.17, 11.73\u201376.89) lymphoma remained significantly elevated when only those diagnosed with celiac before LPD were considered (<jats:italic>n<\/jats:italic> = 24, NHL SIR = 4.47, 95% CI = 2.86\u20136.44). Patients who developed LPD were older at time of celiac disease diagnosis (57.9 \u00b1 15.5 versus 42.5 \u00b1 17.4 years, <jats:italic>P<\/jats:italic> &lt; 0.0001) and more likely to present with diarrhea (60.0% versus 39.8% <jats:italic>P<\/jats:italic> = 0.016), abdominal pain (17.5% versus 5.5% <jats:italic>P<\/jats:italic> = 0.0046), and\/or weight loss (12.5% versus 4.0%, <jats:italic>P<\/jats:italic> = 0.028). EATL patients had a shorter average survival than non\u2010EATL NHL patients (3.2 versus 15.0 years, <jats:italic>P<\/jats:italic> = 0.016). The incidence of LPD is increased in celiac disease patients. Those diagnosed later in life who present with symptoms of malabsorption are more likely to be diagnosed with LPD. Am. J. Hematol. 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23237","type":"journal-article","created":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T12:46:30Z","timestamp":1335444390000},"page":"754-759","source":"Crossref","is-referenced-by-count":25,"title":["Incidence of lymphoproliferative disorders in patients with celiac disease"],"prefix":"10.1002","volume":"87","author":[{"given":"Lori A.","family":"Leslie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Lebwohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred I.","family":"Neugut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Gregory Mears","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govind","family":"Bhagat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.R.","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,28]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071600"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.03.059"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/jcgh.2003.50004"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1320"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-006-9002-4"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38169.486701.7C"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.13.1566"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(03)00302-4"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200405000-00008"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.09.031"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj004"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.032094"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24287"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.11.1413"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq564"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-011-9818-4"},{"key":"e_1_2_5_18_2","unstructured":"Available at:http:\/\/www.seer.cancer.gov\/seerstat. 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