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We genotyped 167 single nucleotide polymorphisms (SNPs) from 30 complement pathway genes in a prospective cohort study of newly diagnosed FL (<jats:italic>N<\/jats:italic> = 107) and DLBCL (<jats:italic>N<\/jats:italic> = 82) patients enrolled at the Mayo Clinic from 2002 to 2005. Cox regression was used to estimate hazard ratios (HRs) for individual SNPs with EFS, adjusting for FLIPI or IPI and treatment. For gene\u2010level analyses, we used a principal components based gene\u2010level test. In gene\u2010level analyses for FL EFS, <jats:italic>CFH<\/jats:italic> (<jats:italic>P<\/jats:italic> = 0.009), <jats:italic>CD55<\/jats:italic> (<jats:italic>P<\/jats:italic> = 0.006), <jats:italic>CFHR5<\/jats:italic> (<jats:italic>P<\/jats:italic> = 0.01), <jats:italic>C9<\/jats:italic> (<jats:italic>P<\/jats:italic> = 0.02), <jats:italic>CFHR1<\/jats:italic> (<jats:italic>P<\/jats:italic> = 0.03), and <jats:italic>CD46<\/jats:italic> (<jats:italic>P<\/jats:italic> = 0.03) were significant at <jats:italic>P<\/jats:italic> &lt; 0.05, and these genes remained noteworthy after accounting for multiple testing (<jats:italic>q<\/jats:italic> &lt; 0.15). SNPs in <jats:italic>CFH<\/jats:italic>, <jats:italic>CFHR1<\/jats:italic>, and <jats:italic>CFHR5<\/jats:italic> showed stronger associations among patients receiving any rituximab, while SNPs from <jats:italic>CD55<\/jats:italic> and <jats:italic>CD46<\/jats:italic> showed stronger associations among patients who were observed. For DLBCL, only <jats:italic>CLU<\/jats:italic> (<jats:italic>P<\/jats:italic> = 0.001) and <jats:italic>C7<\/jats:italic> (<jats:italic>P<\/jats:italic> = 0.03) were associated with EFS, but did not remain noteworthy after accounting for multiple testing (<jats:italic>q<\/jats:italic>&gt;0.15). Genes from the regulators of complement activation (<jats:italic>CFH<\/jats:italic>, <jats:italic>CD55<\/jats:italic>, <jats:italic>CFHR1<\/jats:italic>, <jats:italic>CFHR5<\/jats:italic>, <jats:italic>CD46<\/jats:italic>) at 1q32\u2013q32.1, along with <jats:italic>C9<\/jats:italic>, were associated with FL EFS after adjusting for clinical variables, and if replicated, these findings add further support for the role of host innate immunity in FL prognosis. Am. J. Hematol. 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.23273","type":"journal-article","created":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T08:29:41Z","timestamp":1337588981000},"page":"880-885","source":"Crossref","is-referenced-by-count":41,"title":["Germline variation in complement genes and event\u2010free survival in follicular and diffuse large B\u2010cell lymphoma"],"prefix":"10.1002","volume":"87","author":[{"given":"Bridget","family":"Charbonneau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Maurer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary S.","family":"Fredericksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive 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